.Cytokine levels in crevicular fluid associated with compliance during periodontal maintenance therapy

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dc.creatorFernando Oliveira Costa
dc.creatorSheila Cavalca Cortelli
dc.creatorTarcília Aparecida Silva
dc.creatorAmanda Almeida Costa
dc.creatorRafael Paschoal Esteves Lima
dc.creatorJosé Roberto Cortelli
dc.creatorLuís Otávio de Miranda Cota
dc.date.accessioned2024-07-22T19:47:55Z
dc.date.accessioned2025-09-09T01:23:37Z
dc.date.available2024-07-22T19:47:55Z
dc.date.issued2018-12-11
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1007/s00784-018-2770-x
dc.identifier.issn1436-3771
dc.identifier.urihttps://hdl.handle.net/1843/71188
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofClinical Oral Investigations
dc.rightsAcesso Restrito
dc.subjectCytokines
dc.subjectCompliance
dc.subjectMaintenance
dc.subjectPeriodontitis
dc.subjectBiomarkers
dc.subjectImmune system
dc.subject.otherCompliance
dc.subject.otherClinical Oral Investigations
dc.subject.otheracesso restrito Luís Otávio de Miranda Cota último professor buscado.Cytokine levels in crevicular fluid associated with compliance during periodontal maintenance therapy busca dia 19/07/2024 julho hora 15 e 01 fao clínica
dc.title.Cytokine levels in crevicular fluid associated with compliance during periodontal maintenance therapy
dc.typeArtigo de periódico
local.citation.epage3526
local.citation.spage3517
local.citation.volume23
local.description.resumoObjectives To longitudinally evaluate the effects of compliance during periodontal maintenance therapy (PMT) on cytokines levels and its relation to periodontal status. Materials and methods Ninety-one eligible individuals were selected from a 6-year prospective study with 212 individuals in PMT. From this total, 28 regular compliers (RC) were randomly selected and matched for age and gender with 28 irregular compliers (IC). All participants were non-smokers and non-diabetic. Periodontal parameters and gingival crevicular fluid samples were collected in 5 times: T1 [prior to active periodontal therapy (APT)], T2 (after APT), T3 (2 years), T4 (4 years), and T5 (6 years). Levels of IL-6, IL-10, IL-1β, TNF-α, and MMP-8 were quantified through ELISA. Results RC presented better clinical periodontal status over time when compared to IC. A significant reduction in the levels of IL-1β, TNF-α, MMP-8, and IL-6 was observed among RC along time (from T1 to T5). Levels of IL-1 were similar among groups. By contrast, levels of IL-6 and TNF-α increased over time in IC individuals. Levels of IL-10 increased among RC and reduced among IC. Conclusions The inflammatory cytokines IL-1, TNF-α, IL-6, and MMP-8 were correlated with worse clinical parameters among IC, while IL-10 was associated with an improvement in clinical parameters among RC. These results reinforce the role of these cytokines in the pathogenesis of periodontitis, as well as their role as markers to monitoring the progression of the periodontitis. Clinical relevance Regular compliance during 6-year period the PMT sustained clinical and immunological benefits obtained after active periodontal therapy.
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.initialsUFMG
local.url.externahttps://link.springer.com/article/10.1007/s00784-018-2770-x

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