B-raf protein immunoexpression in hepatocellular carcinoma due to hepatitis c virus related cirrhosis

Página do item simplificado
dc.creatorPaula Piedade Garcia
dc.creatorRonniel Morais Albuquerque
dc.creatorFernanda Maria Farage Osório
dc.creatorCláudia Alves Couto
dc.creatorAgnaldo Soares Lima
dc.creatorPaula Vieira Teixeira Vidigal
dc.date.accessioned2023-11-09T22:11:02Z
dc.date.accessioned2025-09-08T23:42:22Z
dc.date.available2023-11-09T22:11:02Z
dc.date.issued2021-10
dc.format.mimetypepdf
dc.identifier.doi10.1590/s0004-2803.202100000-76
dc.identifier.issn16784219
dc.identifier.urihttps://hdl.handle.net/1843/60754
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofArquivos de Gastroenterologia
dc.rightsAcesso Aberto
dc.subjectCarcinoma, Hepatocellular
dc.subjectProto-Oncogene Proteins B-raf
dc.subjectHepacivirus
dc.subject.otherHepatocellular carcinoma
dc.subject.otherB-Raf
dc.subject.otherhepatitis C virus
dc.titleB-raf protein immunoexpression in hepatocellular carcinoma due to hepatitis c virus related cirrhosis
dc.typeArtigo de periódico
local.citation.epage423
local.citation.issue4
local.citation.spage419
local.citation.volume58
local.description.resumoBackground – Hepatocarcinogenesis is a multistep process that lead to genetic changes in hepatocytes resulting in neoplasia. However, the mechanisms of malignant transformation seem to differ widely. To know carcinogenesis mechanisms is essential to develop new treatment and prevention methods. Objective – The aim of this study is to analyze B-Raf protein immunoexpression in explants with hepatocellular carcinoma (HCC) related to hepatitis C (HCV), in adjacent cirrhotic tissue and in normal livers. We also associated the immunoexpression with known HCC related histopathogical prognostic features. Methods – Livers from 35 patients with HCV related cirrhosis and HCC that underwent liver transplantation or hepatectomy at Clinical Hospital – UFMG and 25 normal livers from necropsy archives were studied. Tumors were classified according to: tumor size, vascular invasion and differentiation grade. B-Raf protein expression was determined by immunohistochemistry. Results – B-Raf was strongly expressed in the HCV cirrhotic parenchyma cytoplasm of 17.1% cases and in 62.9% of HCC samples. Strong B-Raf protein staining was associated with tumor tissue (P<0.0001; OR=8.18 (2.62–26.63)). All normal livers showed weak or negative expression for B-Raf. There was no significant association among B-Raf scores and tumor differentiation grade (P=0.9485), tumor size (P=0.4427) or with vascular invasion (P=0.2666). Conclusion – We found B-Raf protein immunostaining difference in normal livers, in the areas of HCV cirrhosis and in the hepatocarcinoma. We did not find association between B-Raf expression and histopathological markers of tumor progression. Our data suggests that B-Raf may play an important role in initial HCC carcinogenesis. Larger studies are needed to validate these observation.
local.publisher.countryBrasil
local.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICA
local.publisher.initialsUFMG
local.url.externahttps://doi.org/10.1590/S0004-2803.202100000-76

Arquivos

Pacote original

Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
B-RAF PROTEIN IMMUNOEXPRESSION IN HEPATOCELLULAR CARCINOMA DUE TO HEPATITIS C VIRUS RELATED CIRRHOSIS pdfa.pdf
Tamanho:
475.68 KB
Formato:
Adobe Portable Document Format
Baixar

Licença do pacote

Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
License.txt
Tamanho:
978 B
Formato:
Plain Text
Descrição:
Baixar

Coleções

Artigo de Periódico

Logo UFMG