Evidence for a role of ACTN3 R577X polymorphism in football player's career progression

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dc.creatorDaniel Barbosa Coelho
dc.creatorEduardo Mendonça Pimenta
dc.creatorIzinara Cruz Rosse
dc.creatorBruno Magalhães de Castro
dc.creatorLenice Kappes Becker
dc.creatorEmerson Cruz de Oliveira
dc.creatorMaria Raquel Santos Carvalho
dc.creatorEmerson Silami Garcia
dc.date.accessioned2023-03-24T18:06:26Z
dc.date.accessioned2025-09-08T23:27:23Z
dc.date.available2023-03-24T18:06:26Z
dc.date.issued2018
dc.identifier.doihttps://doi.org/10.1055/a-0753-4973
dc.identifier.issn0172-4622
dc.identifier.urihttps://hdl.handle.net/1843/51208
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofInternational Journal of Sports Medicine
dc.rightsAcesso Restrito
dc.subjectJogadores de futebol
dc.subjectPolimorfismo genético
dc.subjectAtletas - Aspectos fisiológicos
dc.subjectAptidão física do atleta
dc.subject.otherFootball
dc.subject.otherAlpha-actinin-3
dc.subject.otherGenotypic distribution
dc.subject.otherAllele distribution
dc.titleEvidence for a role of ACTN3 R577X polymorphism in football player's career progression
dc.typeArtigo de periódico
local.citation.epage1093
local.citation.issue14
local.citation.spage1088
local.citation.volume39
local.description.resumoThe aim was to investigate a possible role of the ACTN3 R577X polymorphism in a Brazilian football player’s career progression. 2 questions were formulated: 1. Does ACTN3 polymorphism affect the probability of an individual being a professional football player? 2. Does this polymorphism affect the progression of the athlete throughout his career? The study included 353 players from first division Brazilian football clubs in the following categories: under-14 (U-14), U-15, U-17, U-20, and professional (PRO). The control group (CON) was composed of 100 healthy non-athletes. The chi-squared test was used to assess differences between the allele and genotype frequencies. Comparing football categories, the XX genotype was less frequent among professional players than in the U-20 (p<0.05) or the U-15 category (p<0.05). The RX genotype also presented more frequently in the PRO category than the U-14 category (p<0.05). Moreover, a trend towards a higher frequency of the RX genotype and a lower frequency of the XX genotype was observed in the professional category compared to U-20. These results suggest that the genotype in the ACTN3 polymorphism affects the probability of a football player progressing throughout his career and becoming professional, meaning that playing football selects against the ACTN3 XX genotype.
local.identifier.orcidhttps://orcid.org/0000-0003-0346-492X
local.identifier.orcidhttps://orcid.org/0000-0001-8968-0089
local.identifier.orcidhttps://orcid.org/0000-0003-2058-689X
local.identifier.orcidhttps://orcid.org/0000-0002-5452-3371
local.identifier.orcidhttps://orcid.org/0000-0002-9462-5719
local.identifier.orcidhttps://orcid.org/0000-0002-8982-4705
local.identifier.orcidhttps://orcid.org/0000-0003-0793-2727
local.publisher.countryBrasil
local.publisher.departmentEEF - DEPARTAMENTO DE ESPORTES
local.publisher.initialsUFMG
local.url.externahttps://www.thieme-connect.com/products/ejournals/abstract/10.1055/a-0753-4973

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