Plasmacytoma and plasma cell myeloma affecting the jaws: a multi-institutional collaborative study

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dc.creatorLucas Lacerda de Souza
dc.creatorRicardo Alves Mesquita
dc.creatorFlávia Sirotheau Correa Pontes
dc.creatorWilfredo Alejandro González-Arriagada
dc.creatorRicardo Martinez Pedraza
dc.creatorBruno Augusto Benevenuto de Andrade
dc.creatorMario José Romañach
dc.creatorCiro Dantas Soares
dc.creatorMaria Goretti Freire de Carvalho
dc.creatorFabio Ramôa Pires
dc.creatorRoman Carlos
dc.creatorCinthia Veronica Bardalez Lopez de Caceres
dc.creatorFelipe Paiva Fonseca
dc.creatorHélder Antônio Rebelo Pontes
dc.creatorOslei Paes Almeida
dc.creatorPablo Agustin Vargas
dc.creatorMárcio Ajudarte Lopes
dc.creatorAlan Roger Santos-Silva
dc.creatorWagner Gomes da Silva
dc.creatorAna Carolina Prado-Ribeiro
dc.creatorThais Bianca Brandão
dc.creatorJuliana Pereira
dc.date.accessioned2023-11-30T20:08:56Z
dc.date.accessioned2025-09-08T23:41:39Z
dc.date.available2023-11-30T20:08:56Z
dc.date.issued2021
dc.identifier.doihttps://doi.org/10.1111/jop.13213
dc.identifier.issn16000714
dc.identifier.urihttps://hdl.handle.net/1843/61592
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Oral Pathology & Medicine
dc.rightsAcesso Restrito
dc.subjectMandible
dc.subjectMultiple myeloma
dc.subjectMouth
dc.subjectPlasmacytoma
dc.subjectNeoplasms
dc.subjectPlasma cells
dc.subjectImmunohistochemistry
dc.subject.otheracesso restrito Plasmacytoma and plasma cell myeloma affecting the jaws: a multi-institutional collaborative study busca dia 13 do 11 2023 assunto mandible fao clínica
dc.subject.othertítulo periódico Journal of oral pathology & medicine (online) data publicação ano 2021
dc.titlePlasmacytoma and plasma cell myeloma affecting the jaws: a multi-institutional collaborative study
dc.typeArtigo de periódico
local.citation.epage621
local.citation.issue6
local.citation.spage613
local.citation.volume50
local.description.resumoBackground: Plasma cell neoplasms are characterized by the proliferation of a single clone of plasma cells with production of a monoclonal immunoglobulin. They can manifest as a single lesion (plasmacytoma) or as multiple lesions (multiple myeloma). Methods: Paraffin-embedded tissue blocks of patients microscopically diagnosed with plasma cell neoplasms in the jaws were retrieved from five pathology files. Data including clinical, radiographic, microscopic and immunohistochemical findings, treatment employed and follow-up status were retrieved from the pathology reports. Results: Fifty-two cases were retrieved (mean age: 59.4 years) without sex predilection. The mandible was the most affected site (67.3%), usually associated with pain and/or paresthesia (53.8%). Lesions in other bones besides the jaws were reported for 24 patients (46.2%). Radiographically, tumours usually presented as poorly defined osteolytic lesions with unilocular or multilocular images, while microscopy revealed diffuse proliferation of neoplastic plasma cells with nuclear displacement and abundant eosinophilic cytoplasm. Two cases were classified as anaplastic, and amyloid deposits were found in two other cases. Immunohistochemistry was positive for plasma cell markers and negative for CD20 and CD3, and monoclonality for kappa light chain predominated. The overall survival rate after 5 years of follow-up was 26.6%. Conclusion: Plasma cell neoplasms are aggressive tumours with a poor prognosis and involvement of the jaws may be the first complaint of the patient. Thus, oral pathologists, head and neck surgeons and dentists should be aware of their clinical, radiographic and microscopic manifestations.
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.initialsUFMG
local.url.externahttps://onlinelibrary.wiley.com/doi/10.1111/jop.13213

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