Trends in hydrogel-based encapsulation technologies for advanced cell therapies applied to limb ischemia

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dc.creatorAna Letícia Rodrigues Costa Lelis
dc.creatorStephanie Michelle Willerth
dc.creatorLucimara Gaziola de la Torre
dc.creatorSang Won Han
dc.date.accessioned2025-09-02T19:46:37Z
dc.date.accessioned2025-09-08T23:47:39Z
dc.date.available2025-09-02T19:46:37Z
dc.date.issued2022-01
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPESP - Fundação de Amparo à Pesquisa do Estado de São Paulo
dc.format.mimetypepdf
dc.identifier.doi10.1016/j.mtbio.2022.100221
dc.identifier.issn25900064
dc.identifier.urihttps://hdl.handle.net/1843/84791
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.rightsAcesso Aberto
dc.subjectHidrogel
dc.subjectTecnologias de encapsulamento
dc.subject.otherIsquemia dos membros
dc.subject.otherExtrusão eletrostática de gotículas
dc.subject.otherMicromoldagem
dc.subject.otherMicrofluídica
dc.subject.otherBioimpressão em 3D
dc.subject.otherHidrogel
dc.titleTrends in hydrogel-based encapsulation technologies for advanced cell therapies applied to limb ischemia
dc.typeArtigo de periódico
local.citation.epage19
local.citation.spage1
local.citation.volume13
local.description.resumoIschemia occurs when blood flow is reduced or restricted, leading to a lack of oxygen and nutrient supply and removal of metabolites in a body part. Critical limb ischemia (CLI) is a severe clinical manifestation of peripheral arterial disease. Atherosclerosis serves as the main cause of CLI, which arises from the deposition of lipids in the artery wall, forming atheroma and causing inflammation. Although several therapies exist for the treatment of CLI, pharmacotherapy still has low efficacy, and vascular surgery often cannot be performed due to the pathophysiological heterogeneity of each patient. Gene and cell therapies have emerged as alternative treatments for the treatment of CLI by promoting angiogenesis. However, the delivery of autologous, heterologous or genetically modified cells into the ischemic tissue remains challenging, as these cells can die at the injection site and/or leak into other tissues. The encapsulation of these cells within hydrogels for local delivery is probably one of the promising options today. Hydrogels, three-dimensional (3D) cross-linked polymer networks, enable manipulation of physical and chemical properties to mimic the extracellular matrix. Thus, specific biostructures can be developed by adjusting prepolymer properties and encapsulation process variables, such as viscosity and flow rate of fluids, depending on the final biomedical application. Electrostatic droplet extrusion, micromolding, microfluidics, and 3D printing have been the most commonly used technologies for cell encapsulation due to their versatility in producing different hydrogel-based systems (e.g., microgels, fibers, vascularized architectures and perfusable single vessels) with great potential to treat ischemic diseases. This review discusses the cell encapsulation technologies associated with hydrogels which are currently used for advanced therapies applied to limb ischemia, describing their principles, advantages, disadvantages, potentials, and innovative therapeutic ideas.
local.publisher.countryBrasil
local.publisher.departmentFAR - DEPARTAMENTO DE ALIMENTOS
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S2590006422000199

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