Paradoxical sleep deprivation causes cardiac dysfunction and the impairment is attenuated by resistance training

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dc.creatorSara Quaglia de Campos Giampá
dc.creatorMarcos Mônico-Neto
dc.creatorMarco Tulio de Mello
dc.creatorHelton de Sá Souza
dc.creatorSergio Tufik
dc.creatorKil Sun Lee
dc.creatorMarcia Kiyomi Koike
dc.creatorAlexandra Alberta Dos Santos
dc.creatorEdnei Luiz Antonio
dc.creatorAndrey Jorge Serra
dc.creatorPaulo José Ferreira Tucci
dc.creatorHanna Karen Moreira Antunes
dc.date.accessioned2024-02-16T16:24:40Z
dc.date.accessioned2025-09-09T01:04:59Z
dc.date.available2024-02-16T16:24:40Z
dc.date.issued2016
dc.description.sponsorshipFAPESP - Fundação de Amparo à Pesquisa do Estado de São Paulo
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0167029
dc.identifier.issn1932-6203
dc.identifier.urihttps://hdl.handle.net/1843/64029
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofPLoS ONE
dc.rightsAcesso Aberto
dc.subjectPrivação do sono
dc.subjectInsuficiência cardíaca
dc.subjectTreino aeróbico
dc.subject.otherSleep deprivation
dc.subject.otherCardiac dysfunction
dc.subject.otherResistance training
dc.titleParadoxical sleep deprivation causes cardiac dysfunction and the impairment is attenuated by resistance training
dc.title.alternativeA privação paradoxal do sono causa disfunção cardíaca e o prejuízo é atenuado pelo treinamento de resistência
dc.typeArtigo de periódico
local.citation.issue11
local.citation.volume11
local.description.resumoBackground: Paradoxical sleep deprivation activates the sympathetic nervous system and the hypothalamus-pituitary-adrenal axis, subsequently interfering with the cardiovascular system. The beneficial effects of resistance training are related to hemodynamic, metabolic and hormonal homeostasis. We hypothesized that resistance training can prevent the cardiac remodeling and dysfunction caused by paradoxical sleep deprivation. Methods: Male Wistar rats were distributed into four groups: control (C), resistance training (RT), paradoxical sleep deprivation for 96 hours (PSD96) and both resistance training and sleep deprivation (RT/PSD96). Doppler echocardiograms, hemodynamics measurements, cardiac histomorphometry, hormonal profile and molecular analysis were evaluated. Results: Compared to the C group, PSD96 group had a higher left ventricular systolic pressure, heart rate and left atrium index. In contrast, the left ventricle systolic area and the left ventricle cavity diameter were reduced in the PSD96 group. Hypertrophy and fibrosis were also observed. Along with these alterations, reduced levels of serum testosterone and insulin-like growth factor-1 (IGF-1), as well as increased corticosterone and angiotensin II, were observed in the PSD96 group. Prophylactic resistance training attenuated most of these changes, except angiotensin II, fibrosis, heart rate and concentric remodeling of left ventricle, confirmed by the increased of NFATc3 and GATA-4, proteins involved in the pathologic cardiac hypertrophy pathway. Conclusions: Resistance training effectively attenuates cardiac dysfunction and hormonal imbalance induced by paradoxical sleep deprivation.
local.identifier.orcidhttps://orcid.org/0000-0001-9983-8812
local.identifier.orcidhttps://orcid.org/0000-0002-9515-1260
local.identifier.orcidhttps://orcid.org/0000-0003-3896-2208
local.identifier.orcidhttps://orcid.org/0000-0003-0525-5371
local.identifier.orcidhttps://orcid.org/0000-0002-2390-2774
local.identifier.orcidhttps://orcid.org/0000-0002-5556-8061
local.identifier.orcidhttps://orcid.org/0000-0002-5407-8183
local.identifier.orcidhttps://orcid.org/0000-0001-9793-670X
local.identifier.orcidhttps://orcid.org/0000-0001-6648-0957
local.publisher.countryBrasil
local.publisher.departmentEEF - DEPARTAMENTO DE ESPORTES
local.publisher.initialsUFMG
local.url.externahttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0167029

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