Use of chitosan as pharmaceutical excipient in ocular drug delivery systems: sterilization and pharmacokinetics

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dc.creatorJuçara Ribeiro França
dc.creatorLeonardo Lima Fuscaldi
dc.creatorTatiana Gomes Ribeiro
dc.creatorGiselle Foureaux
dc.creatorAina Liz Alves Cesar
dc.creatorRachel Oliveira Castilho
dc.creatorSebastião Cronemberger
dc.creatorAnderson José Ferreira
dc.creatorSimone Odília Antunes Fernandes
dc.creatorValbert Nascimento Cardoso
dc.creatorAndré Augusto Gomes Faraco
dc.date.accessioned2022-05-18T23:30:03Z
dc.date.accessioned2025-09-08T23:53:28Z
dc.date.available2022-05-18T23:30:03Z
dc.date.issued2020-07
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.description.sponsorshipOutra Agência
dc.identifier.doi10.1002/jbm.b.34560
dc.identifier.issn1552-4973
dc.identifier.urihttps://hdl.handle.net/1843/41810
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Biomedical Materials Research Part B: Applied Biomaterials
dc.rightsAcesso Restrito
dc.subjectQuitosana
dc.subjectFarmacocinética
dc.subjectAdministração ocular de drogas
dc.subject.otherChitosan
dc.subject.otherExcipient
dc.subject.otherOcular drug delivery
dc.subject.otherPharmacokinetics
dc.subject.otherSterilization
dc.titleUse of chitosan as pharmaceutical excipient in ocular drug delivery systems: sterilization and pharmacokinetics
dc.typeArtigo de periódico
local.citation.epage2237
local.citation.issue5
local.citation.spage2227
local.citation.volume108
local.description.resumoThe use of chitosan as a pharmaceutical excipient in the ocular field is already established. Nevertheless, some aspects related to its ocular administration, such as sterilization and excipient's pharmacokinetics, remain unclear. So, in this study, we evaluated those two relevant aspects, related to chitosan administration in eye. We used chitosan-based ocular inserts (CI) as formulation model. CI were produced by solvent/casting method and sterilized by saturated steam. Sterilization was confirmed by direct inoculation of inserts in suitable microbiological growth media. Physicochemical characterization of inserts before and after sterilization was performed. Results suggested that, although steam sterilization changed the arrangement of the matrix, the heat and the humidity did not modify the structure of the main polymeric chain. Pharmacokinetics of CI radiolabeled with technetium-99m (99mTc) was assessed by scintigraphic images and ex vivo biodistribution study, after ocular administration in male Wistar rats. Scintigraphic and images analysis and ex vivo biodistribution study showed that the insert remained mainly in the eye until 6 hr after administration and its degradation products began to migrate to the abdominal cavity after 18 hr. Together, these data represent an important step forward the manufacturing and the clinical application of CI in the ophthalmic field.
local.publisher.countryBrasil
local.publisher.departmentFAR - DEPARTAMENTO DE ALIMENTOS
local.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS
local.publisher.departmentFAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOS
local.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIA
local.publisher.departmentMED - DEPARTAMENTO DE OFTALMOLOGIA E OTORRINOLARINGOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://onlinelibrary.wiley.com/doi/10.1002/jbm.b.34560

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