Early serum biomarker networks in infants with distinct retinochoroidal lesion status of congenital toxoplasmosis

Página do item simplificado
dc.creatorThádia Evelynde Araújo
dc.creatorDaniel Vítor de Vasconcelos Santos
dc.creatorJosé Nélio Januário
dc.creatorAndréa Teixeira-carvalho
dc.creatorRicardo Wagner Almeida Vitor
dc.creatorEloisa Amália Vieira Ferro
dc.creatorOlindo Assis Martins-filho
dc.creatorJordana Grazziela Coelho-dos-reis
dc.creatorSamantha Ribeiro Béla
dc.creatorAna Carolina Aguiar Vasconcelos Carneiro
dc.creatorAnderson Silva Machado
dc.creatorLudmila Melo Cardoso
dc.creatorÁgata Lopes Ribeiro
dc.creatorMichelle Hallais França Dias
dc.creatorGláucia Manzan Queiroz Andrade
dc.date.accessioned2023-06-23T22:37:17Z
dc.date.accessioned2025-09-09T00:36:58Z
dc.date.available2023-06-23T22:37:17Z
dc.date.issued2017-02-28
dc.format.mimetypepdf
dc.identifier.doi10.1016/j.cyto.2017.02.018
dc.identifier.issn10434666
dc.identifier.urihttps://hdl.handle.net/1843/55300
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofCytokine
dc.rightsAcesso Restrito
dc.subjectToxoplasmose Congênita
dc.subjectCoriorretinopatia de Birdshot
dc.subjectCrianças
dc.subjectBiomarcadores Farmacológicos
dc.subject.otherCongenital toxoplasmosis
dc.subject.otherRetinochoroiditis
dc.subject.otherInfants
dc.subject.otherBiomarkers
dc.titleEarly serum biomarker networks in infants with distinct retinochoroidal lesion status of congenital toxoplasmosis
dc.typeArtigo de periódico
local.citation.epage112
local.citation.spage102
local.citation.volume95
local.description.resumoThe present study characterized the early changes in the serum chemokines/cytokine signatures and net works in infants with congenital-toxoplasmosis/(TOXO) as compared to non-infected-controls/(NI).TOXO were subgrouped according to the retinochoroidal lesion status as no-lesion/(NL), active-lesion/(ARL), active/cicatricial-lesion/(ACRL) and cicatricial-lesion/(CRL). The results showed that TOXO displayprominent chemokine production mediated by IL-8/CXCL8, MIG/CXCL9, IP-10/CXCL10 and RANTES/CCL5. Additionally, TOXO is accompanied by mixed proinflammatory/regulatory cytokine pattern mediated by IL-6, IFN-c, IL-4, IL-5 and IL-10. While TNF appears as a putative biomarker for NL and IFN-c/IL-5 as immunological features for ARL, IL-10 emerges as a relevant mediator in ACRL/CRL. IL-8/CXCL8 and IP-10/CXCL10 are broad-spectrum indicators of ocular disease, whereas TNF is a NL biomarker, IFN-c and MIG/CXCL9 point out to ARL; and IL-10 is highlighted as a genuine serum biomarker of ACRL/CRL.The network analysis demonstrated a broad chemokine/cytokine crosstalk with divergences in the molecular signatures in patients with different ocular lesions during congenital toxoplasmosis.
local.identifier.orcidhttps://orcid.org/0000-0002-0912-3782
local.publisher.countryBrasil
local.publisher.departmentICB - DEPARTAMENTO DE MICROBIOLOGIA
local.publisher.departmentICB - DEPARTAMENTO DE PARASITOLOGIA
local.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICA
local.publisher.departmentMED - DEPARTAMENTO DE OFTALMOLOGIA E OTORRINOLARINGOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S1043466617300510?via%3Dihub

Arquivos

Licença do pacote

Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
License.txt
Tamanho:
1.99 KB
Formato:
Plain Text
Descrição:
Baixar

Coleções

Artigo de Periódico

Logo UFMG