Fitting pieces into the puzzle: the impact of titanium-based dental implant surface modifications on bacterial accumulation and polymicrobial infections

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dc.creatorRaphael Costa
dc.creatorJoão Gabriel Silva Souza
dc.creatorBruna e Nagay
dc.creatorMartina Bertolini
dc.creatorBarbara Emanuele Costa-Oliveira
dc.creatorAline Araújo Sampaio
dc.creatorBelén Retamal-Valdes
dc.creatorJamil Shibli
dc.creatorMagda Feres
dc.creatorValentim Adelino Ricardo Barão
dc.date.accessioned2023-06-20T11:40:48Z
dc.date.accessioned2025-09-08T23:45:00Z
dc.date.available2023-06-20T11:40:48Z
dc.date.issued2021
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.description.sponsorshipFAPESP - Fundação de Amparo à Pesquisa do Estado de São Paulo
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1016/j.cis.2021.102551
dc.identifier.issn00018686
dc.identifier.urihttps://hdl.handle.net/1843/55143
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofAdvances in Colloid and Interface Science
dc.rightsAcesso Restrito
dc.subjectBiofilms
dc.subjectDental implants
dc.subjectInfections
dc.subjectTitanium
dc.subjectAnti-bacterial agents
dc.titleFitting pieces into the puzzle: the impact of titanium-based dental implant surface modifications on bacterial accumulation and polymicrobial infections
dc.typeArtigo de periódico
local.citation.spage102551
local.citation.volume298
local.description.resumoPolymicrobial infection is the main cause of dental implant failure. Although numerous studies have reported the ability of titanium (Ti) surface modifications to inhibit microbial adhesion and biofilm accumulation, the majority of solutions for the utilization of Ti antibacterial surfaces have been testedin in vitro and animal models, with only a few developed surfaces progressing into clinical research. Motivated by this huge gap, we critically reviewed the scientific literature on the existing antibacterial Ti surfaces to help understand these surfaces' impact on the "puzzle" of undesirable dental implant-related infections. This manuscript comprises three main sections: (i) a narrative review on topics related to oral biofilm formation, bacterial-implant surface interactions, and on how implant-surface modifications can influence microbial accumulation; (ii) a critical evidence-based review to summarize pre-clinical and clinical studies in an attempt to "fit pieces into the puzzle" to unveil the best way to reduce microbial loads and control polymicrobial infection around dental implants showed by the current in vivo evidence; and (iii) discussion and recommendations for future research testing emerging antibacterial implant surfaces, connecting basic science and the requirements for future clinical translation. The findings of the present review suggest no consensus regarding the best available Ti surface to reduce bacterial colonization on dental implants. Smart release or on-demand activation surface coatings are a "new piece of the puzzle", which may be the most effective alternative for reducing microbial colonization on Ti surfaces, and future studies should focus on these technologies
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/abs/pii/S0001868621001925?via%3Dihub

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