Synthetic curcumin analogues present antiflavivirus activity in vitro with potential multiflavivirus activity from a thiazolylhydrazone moiety

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dc.creatorMateus Sá Magalhães Serafim
dc.creatorThales Kronenberger
dc.creatorRenata Barbosa de Oliveira
dc.creatorErna Geessien Kroon
dc.creatorJônatas Santos Abrahão
dc.creatorBruno Eduardo Fernandes Mota
dc.creatorVinícius Gonçalves Maltarollo
dc.date.accessioned2025-02-14T21:16:51Z
dc.date.accessioned2025-09-09T00:38:15Z
dc.date.available2025-02-14T21:16:51Z
dc.date.issued2023-03-25
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.3390/futurepharmacol3020022
dc.identifier.issn2673-9879
dc.identifier.urihttps://hdl.handle.net/1843/80107
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofFuture Pharmacology
dc.rightsAcesso Aberto
dc.subjectVírus da Febre Amarela
dc.subjectZika virus
dc.subjectVírus da Dengue
dc.subject.otherCurcumin analogues
dc.subject.otherDengue virus serotype 2
dc.subject.otherYellow fever virus
dc.subject.otherZika virus
dc.titleSynthetic curcumin analogues present antiflavivirus activity in vitro with potential multiflavivirus activity from a thiazolylhydrazone moiety
dc.typeArtigo de periódico
local.citation.epage378
local.citation.issue2
local.citation.spage364
local.citation.volume3
local.description.resumoArboviral diseases caused by flaviviruses, such as dengue, are a continuing threat and major concern worldwide, with over three billion people estimated to be living with the risk of dengue virus (DENV) infections. There are thus far no antiviral drugs available for treatment, and limited or no vaccines are available. Curcumin and seven synthetic analogues were evaluated for their antiviral activity against dengue virus serotype 2, yellow fever virus and Zika virus, as well as for their cytotoxicity in Vero cells, both by employing MTT assays. Compounds 6 and 7, which present a thiazolylhydrazone moiety, showed moderate activity against all three flaviviruses, with selectivity index (SI) values up to 4.45. In addition, the envelope protein (E) was predicted as the potential target inhibited by both compounds, supported by molecular docking and dynamics simulation analysis. We hope that this data can contribute to the development of new curcumin antiviral analogues in the near future and can help in the search for new promising compounds as potential therapeutic agents to treat flaviviruses infections.
local.identifier.orcidhttps://orcid.org/0000-0002-7505-8659
local.identifier.orcidhttps://orcid.org/0000-0001-6933-7590
local.identifier.orcidhttps://orcid.org/0000-0002-0980-7375
local.identifier.orcidhttps://orcid.org/0000-0003-2721-3826
local.identifier.orcidhttps://orcid.org/0000-0001-9420-1791
local.identifier.orcidhttps://orcid.org/0000-0001-9675-5907
local.publisher.countryBrasil
local.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS
local.publisher.departmentFAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOS
local.publisher.departmentICB - DEPARTAMENTO DE MICROBIOLOGIA
local.publisher.departmentICX - DEPARTAMENTO DE QUÍMICA
local.publisher.initialsUFMG
local.url.externahttps://www.mdpi.com/2673-9879/3/2/22

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