Clinicopathological analysis of head and neck rhabdomyosarcoma: a series of 10 cases and literature review

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dc.creatorFlávia Sirotheau Corrêa Pontes
dc.creatorJonas Ikikame de Oliveira
dc.creatorLucas Lacerda de Souza
dc.creatorOslei Paes de Almeida
dc.creatorEduardo Rodrigues Fregnani
dc.creatorRafael Sarlo Vilela
dc.creatorWanessa Miranda-Silva
dc.creatorFelipe Paiva Fonseca
dc.creatorHélder Antônio Rebelo Pontes
dc.date.accessioned2023-11-06T20:46:16Z
dc.date.accessioned2025-09-08T23:20:08Z
dc.date.available2023-11-06T20:46:16Z
dc.date.issued2018-02-25
dc.identifier.doihttps://doi.org/10.4317%2Fmedoral.22106
dc.identifier.issn16986946
dc.identifier.urihttps://hdl.handle.net/1843/60526
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofMedicina Oral Patologia Oral y Cirugia Bucal
dc.rightsAcesso Aberto
dc.subjectRhabdomyosarcoma
dc.subjectHead
dc.subjectNeck
dc.subjectMouth
dc.subjectDrug therapy
dc.subjectNeoplasms
dc.subjectMedical records
dc.subject.otherrevista Medicina oral patologia oral y cirugia bucal
dc.subject.otherfao clinica assunto rabdomiossarcoma busca dia 19 do 09 ano 2023 acesso open pmc key word: Rhabdomyosarcoma, soft tissue tumors, head and neck, oral cavity, chemotherapy .título:
dc.titleClinicopathological analysis of head and neck rhabdomyosarcoma: a series of 10 cases and literature review
dc.typeArtigo de periódico
local.citation.epagee197
local.citation.issue2
local.citation.spagee188
local.description.resumoBackground To describe the clinicopathological characteristics of a series of head and neck rhabdomyosarcoma (RMS) and to review the literature. Material and Methods Cases diagnosed as RMS affecting the head and neck region were retrospectively retrieved from the files of two Brazilian institutions from January 2006 to January 2017. Data on clinical features (sex, age and affected site), microscopic subtype, immunohistochemical results, treatment employed and follow-up status were obtained from the patient’s medical charts. Results During the period considered, 10 cases of RMS were identified. Females predominated (4M:6F), the mean age at diagnosis was 16.5 years-old and the orbit was the most affected site (4 cases). Microscopically, most cases were classified as embryonal RMS (6 cases) and the Desmin/Myogenin/Myo-D1 immunohistochemical positivity was useful to confirm the diagnosis. Chemotherapy and radiotherapy were applied to 9 and 8 patients respectively, whereas 2 patients were treated by surgery. Recurrences occurred in 3 patients and distant metastasis in 2 cases. Nine patients were alive in their last follow-up, 3 of them with disease, whereas 1 patient died due to the disease. Conclusions Head and neck RMS is an aggressive malignant neoplasm which demands especial concern to achieve early diagnosis and successful treatment.
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.initialsUFMG
local.url.externahttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5911360/

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