Activation of BDNF/trkB/Akt pathway is associated with aggressiveness and unfavorable survival in oral squamous cell carcinoma

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dc.creatorJuliana Kern de Moraes
dc.creatorVivian Petersen Wagner
dc.creatorFelipe Paiva Fonseca
dc.creatorGleyson Kleber do Amaral Silva
dc.creatorPablo Agustin Vargas
dc.creatorManoela Domingues Martins
dc.creatorCaroline Brunetto de Farias
dc.creatorEmily Ferreira Salles Pilar
dc.creatorLauro Gregianin
dc.creatorRafael Roesler
dc.date.accessioned2023-10-19T23:54:39Z
dc.date.accessioned2025-09-09T01:27:16Z
dc.date.available2023-10-19T23:54:39Z
dc.date.issued2019
dc.identifier.doihttps://doi.org/10.1111/odi.13190
dc.identifier.issn1354523X
dc.identifier.urihttps://hdl.handle.net/1843/59785
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofOral Diseases
dc.rightsAcesso Restrito
dc.subjectBiomarkers
dc.subjectHead and neck neoplasms
dc.subjectImmunohistochemistry
dc.subjectPredictive value of tests
dc.subjectPrognosis
dc.subjectBrain-derived neurotrophic factor
dc.subjectReceptor, trkB
dc.subjectSquamous cell carcinoma of head and neck
dc.subjectProteins
dc.subjectMouth mucosa
dc.subjectLeukoplakia, oral
dc.subjectSurvival
dc.subjectAging
dc.titleActivation of BDNF/trkB/Akt pathway is associated with aggressiveness and unfavorable survival in oral squamous cell carcinoma
dc.typeArtigo de periódico
local.citation.epage1936
local.citation.issue8
local.citation.spage1925
local.description.resumoObjectives: To evaluate the expression of brain-derived neurotrophic factor (BDNF), its tyrosine kinase receptor B (TrkB), and two downstream targets of this pathway, Akt and ribosomal protein S6 (RPS6), in normal oral mucosa (NOM), oral leukoplakia (OL), and oral squamous cell carcinoma (OSCC) and correlate this expression with OSCC patients' outcomes, cell senescence, and "stemness" profile. Materials and methods: Ten cases of NOM, 32 OL, and 72 primary OSCC were included. Immunohistochemical analysis for BDNF, TrkB, p-TrkB, p-Akt, and p-RPS6 was performed. Cell senescence and stemness profile of OSCC were evaluated through p16 and BMI-1 immunohistochemical expression, respectively. The slides were scanned into high-resolution images and quantified through digital analysis. Results: Oral squamous cell carcinoma presented increased expression of BDNF/TrkB/Akt pathway compared to NOM and OL. OSCC diagnosed in advanced clinical stages presented an upregulation of BDNF and p-TrkB. BDNF and p-Akt were identified as predictors of poor disease-specific survival. The increase in stemness profile was correlated with a decrease in p-TrkB and p-Akt expression. Conclusions: BDNF/TrkB/Akt pathway is significantly increased in malignant cells from OSCC. Moreover, BDNF and Akt represent biomarkers capable to predict a poor prognosis of OSCC patients.
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.initialsUFMG
local.url.externahttps://onlinelibrary.wiley.com/doi/10.1111/odi.13190

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