Effectiveness of photobiomodulation therapy in radiation dermatitis: a systematic review and meta-analysis
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Universidade Federal de Minas Gerais
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Artigo de periódico
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Membros da banca
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Purpose: To evaluate the effectiveness of photobiomodulation therapy (PBMT) in the prevention and treatment of radiation dermatitis (RD). Methods: A systematic review was conducted using seven databases and the gray literature. We performed a meta-analysis to summarize the effect sizes of response rates (RRs). Results: We included seven clinical trials. Breast cancer patients receiving PBMT developed more grade 1 RD than the control group (RR 1.55, 95 % CI 1.14–2.10, I 2 = 51 %). PBMT appears to prevent RD grade 2 (RR 0.33, 95 % CI 0.09–1.23, I 2 = 85 %) and RD grade 3 (RR 0.21, 95 % CI 0.05–0.94, I 2 = 0%) with very low certainty of evidence. Conclusions: There is very low certainty of evidence that PBMT was effective in the prevention of RD. However, PBMT showed a significant effect to prevent grade 3 RD in breast cancer patients. Thus, further randomized clinical trials are required to confirm the promising effect of PBMT in RD.
Abstract
Assunto
Radiotherapy, Radiodermatitis, Laser therapy, Low-level light therapy, Meta-analysis
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Radiotherapy, Radiodermatitis, Laser therapy, Low-level light therapy, Photobiomodulation, Meta-analysis
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https://www.sciencedirect.com/science/article/pii/S1040842821001372