Overexpression of immunosuppressive cytokines is associated with poorer clinical stage of oral squamous cell carcinoma

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dc.creatorDiego Antonio Costa Arantes
dc.creatorNádia Lago Costa
dc.creatorElismauro Francisco Mendonça
dc.creatorTarcília Aparecida da Silva
dc.creatorAline Carvalho Batista
dc.date.accessioned2025-03-27T20:32:37Z
dc.date.accessioned2025-09-09T01:08:02Z
dc.date.available2025-03-27T20:32:37Z
dc.date.issued2016-01
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1016/j.archoralbio.2015.10.013
dc.identifier.issn1879-1506
dc.identifier.urihttps://hdl.handle.net/1843/81029
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofArchives of Oral Biology
dc.rightsAcesso Restrito
dc.subjectImmune tolerance
dc.subjectInterleukin-10
dc.subjectMouth neoplasms
dc.subjectSquamous cell carcinoma of head and neck
dc.subjectCytokines
dc.subjectProteins
dc.subjectMesenchymal stem cells
dc.subject.otherImmunosuppression
dc.subject.otherInterleukin-10
dc.subject.otherOral cancer
dc.subject.otherOral squamous cell carcinoma
dc.subject.otherTransforming growth factor β
dc.titleOverexpression of immunosuppressive cytokines is associated with poorer clinical stage of oral squamous cell carcinoma
dc.typeArtigo de periódico
local.citation.epage35
local.citation.spage28
local.citation.volume61
local.description.resumoObjective: The aim of this study was to evaluate the expression of IL-10 and TGF-β2 in oral squamous cell carcinoma (OSCC) and its relationship with prognostic clinical and microscopic parameters. Design: Immunohistochemistry was used to assess the expression of IL-10 and TGF-β2 in OSCC samples from 43 patients who had undergone surgical excision and neck dissection. Metastatic lymph nodes were included in the study (n=23). Samples of healthy oral mucosa (n=20) were used as controls. The sections were evaluated using a semi-quantitative method in conjunction with staining intensity. Results: Our findings showed that the expression of IL-10 and TGF-β2 by neoplastic and stromal cells was high in most of the OSCC samples (>70% of samples), especially when compared to the controls (≅10% of samples) (P<0.05). OSCC neoplastic cells in cervical lymph nodes were also positive for IL-10 and TGF-β2. An association between high expression of IL-10 by neoplastic cells and advanced clinical stage (T3-T4) was verified (P=0.02). Although not statistically significant, the expression of TGF-β2 was also augmented in advanced stage tumours. Conclusions: These data suggest that the ability of OSCC neoplastic cells to secrete immunosuppressive cytokines could contribute to clinical progression by maintaining a microenvironment conducive to evasion and tumour proliferation.
local.identifier.orcidhttps://orcid.org/0000-0002-1306-747X
local.identifier.orcidhttps://orcid.org/0000-0002-6751-3279
local.identifier.orcidhttps://orcid.org/0000-0001-9623-7835
local.identifier.orcidhttps://orcid.org/0000-0002-2117-5593
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S0003996915300613?via%3Dihub

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