Cytokines and chemokines associated with treg/th17 response in chronic inflammatory periapical disease

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dc.creatorAline Maria do Couto
dc.creatorAndré Oliveira Naufel de Toledo
dc.creatorCelso Martins Queiroz-junior
dc.creatorPatrícia Caldeira Patrícia Carlos Caldeira
dc.creatorMila Fernandes Moreira Madeira
dc.creatorMaria Cássia Ferreira de Aguiar
dc.date.accessioned2025-08-14T20:36:32Z
dc.date.accessioned2025-09-08T23:17:28Z
dc.date.available2025-08-14T20:36:32Z
dc.date.issued2019
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1590/1807-3107bor-2019.vol33.0093
dc.identifier.issn1807-3107
dc.identifier.urihttps://hdl.handle.net/1843/84380
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofBrazilian Oral Research
dc.rightsAcesso Aberto
dc.subjectCytokines
dc.subjectEndodontics
dc.subjectPeriapical diseases
dc.subjectT-lymphocytes, regulatory
dc.subjectTh17 cells
dc.subjectTransforming Growth Factor beta
dc.subjectChemokine CCL4
dc.subjectChemokine CCL20
dc.subjectInterleukin-10
dc.subjectInterleukin-17
dc.subjectDental pulp necrosis
dc.subject.otherCytokines
dc.subject.otherEndodontics
dc.subject.otherPeriapical diseases
dc.subject.otherT-lymphocytes, regulatory
dc.subject.otherTh17 cells
dc.titleCytokines and chemokines associated with treg/th17 response in chronic inflammatory periapical disease
dc.typeArtigo de periódico
local.citation.epage8
local.citation.spage1
local.citation.volume33
local.description.resumoCytokines and chemokines have a fundamental role in the maintenance of inflammation and bone response, which culminate in the development of chronic periapical lesions. Regulatory (Treg) and Th17 cytokines play a key role in regulating the immune response involved in this process. The aim of this study was to investigate the role of Treg and Th17 cells in chronic inflammatory periapical disease, by comparing the expression of the immunoregulatory mediators TGF-β, IL-10, CCL4, and the proinflammatory IL-17 and CCL20 in the periapical tissue of teeth with pulp necrosis, with and without associated chronic lesions. Eighty-six periapical tissue samples were obtained from human teeth. The samples were divided into three groups: pulp necrosis with a periapical lesion (n=26); pulp necrosis without a periapical lesion (n=30), and control (n=30). All samples were submitted to histopathological analysis and cytokine and chemokine measurement through ELISA. Statistical analyses were done with Kruskal-Wallis and Mann-Whitney tests and Spearman correlation. The group with pulp necrosis and a periapical lesion showed a higher expression of CCL4 and TGF-β in comparison with pulp necrosis without a lesion. CCL20 was higher in the group with a periapical lesion when compared to the control. In all groups there was a weak positive correlation between IL-17/CCL20, IL-10/CCL4, and IL-17/TGF-β. Both types of cytokines, pro-inflammatory and immunoregulatory, occur simultaneously in periapical tissue. However, a rise in immunosuppressive cytokines and chemokines (CCL4 and TGF-β) in periapical lesions suggests a role of these cytokines in stable periapical disease.
local.identifier.orcidhttps://orcid.org/0000-0003-4306-2554
local.identifier.orcidhttps://orcid.org/0000-0002-7884-7709
local.identifier.orcidhttps://orcid.org/0000-0002-9179-0145
local.identifier.orcidhttps://orcid.org/0000-0002-1770-9978
local.identifier.orcidhttps://orcid.org/0000-0001-5134-3466
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.departmentICB - DEPARTAMENTO DE MICROBIOLOGIA
local.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://www.scielo.br/j/bor/a/ghNQX5CCPQ4Dx7HC5F4jMDv/?lang=en

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