Efficacy of scaffold-mediated localized chemotherapy in cancer: a systematic review of current research

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dc.creatorArchana Gupta
dc.creatorPeter Thomson
dc.creatorPeter Brennan
dc.creatorSupriya Kheur
dc.creatorGururaj Arakeri
dc.creatorThirumal Raj
dc.creatorRavindra Badhe
dc.creatorShankargouda Patil
dc.creatorVishal Rao
dc.creatorShekhar Patil
dc.creatorRicardo Santiago Gomez
dc.date.accessioned2024-12-02T19:23:36Z
dc.date.accessioned2025-09-09T00:35:08Z
dc.date.available2024-12-02T19:23:36Z
dc.date.issued2020
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1111/jop.12994
dc.identifier.issn1600-0714
dc.identifier.urihttps://hdl.handle.net/1843/78406
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Oral Pathology & Medicine
dc.rightsAcesso Restrito
dc.subjectNeoplasms
dc.subjectDrug therapy
dc.subjectResearch
dc.subjectSystematic review
dc.subjectPharmaceutical preparations
dc.subjectToxicity
dc.subject.otherCancer
dc.subject.otherChemotherapy
dc.subject.otherResearch
dc.subject.otherScaffold
dc.subject.otherSystemic review
dc.titleEfficacy of scaffold-mediated localized chemotherapy in cancer: a systematic review of current research
dc.typeArtigo de periódico
local.citation.epage385
local.citation.issue5
local.citation.spage375
local.citation.volume49
local.description.resumoObjective: To assess the efficacy of scaffold-mediated localized chemotherapy in cancer. Methods: Databases including PubMed, Cochrane Library, and SCOPUS were searched for articles reporting the use of scaffold-mediated localized drug delivery in cancer. Essential data including scaffold fabrication material and methods, drug dosage and release duration and its effect on the cancer cells were extracted. Results: 15 articles out of 60 screened, fulfilled the eligibility criteria. Among the 15 studies, 5 studies included only cell lines and 2 studies were on mouse models, while 8 studies involved a combination of cell lines and mouse models. Scaffold materials included both synthetic polymers such as poly-lactide, polycaprolactone and natural materials including d-periosteum and human micro-fragmented adipose tissueA wide number of other variables included the fabrication procedure, drugs used, and the methods used to assess the effects on cancer. As a result, it was not possible to make any direct comparison of the efficacy of the therapeutic strategy used in each of these studies. Conclusion: Irrespective of the many variables, a common consensus in all the included studies was that scaffold mediated localized drug delivery effectively reduced cancer cell viability by increasing drug bioavailability to the target tissue, while its localized effect reduced the risk of systemic toxicity.
local.identifier.orcidhttps://orcid.org/0000-0003-4804-3264
local.identifier.orcidhttps://orcid.org/0000-0002-5050-4288
local.identifier.orcidhttps://orcid.org/0000-0002-2440-3547
local.identifier.orcidhttps://orcid.org/0000-0002-2032-4526
local.identifier.orcidhttps://orcid.org/0000-0002-1079-1024
local.identifier.orcidhttps://orcid.org/0000-0002-9919-8154
local.identifier.orcidhttps://orcid.org/0000-0001-6167-5114
local.identifier.orcidhttps://orcid.org/0000-0001-8770-8009
local.identifier.orcidhttps://orcid.org/0000-0002-2007-7975
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.initialsUFMG
local.url.externahttps://onlinelibrary.wiley.com/doi/10.1111/jop.12994

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