Oral lichen sclerosus: a rare case report and review of the literature

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dc.creatorHelvécio Marangon Júnior
dc.creatorPaulo Eduardo Alencar Souza
dc.creatorRodrigo Villamarim Soares
dc.creatorRicardo Santiago Gomez
dc.creatorGustavo Henrique de Mattos Pereira
dc.creatorMartinho Campolina Rebello Horta
dc.date.accessioned2024-11-13T16:39:24Z
dc.date.accessioned2025-09-08T23:51:59Z
dc.date.available2024-11-13T16:39:24Z
dc.date.issued2016-11-02
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1007/s12105-016-0766-x
dc.identifier.issn1936-0568
dc.identifier.urihttps://hdl.handle.net/1843/78016
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofHead and Neck Pathology
dc.rightsAcesso Restrito
dc.subjectLichen sclerosus et atrophicus
dc.subjectMouth mucosa
dc.subjectHyperkeratosis, epidermolytic
dc.subjectLip
dc.subjectWounds and injuries
dc.subjectBiopsy
dc.subject.otherHistopathology
dc.subject.otherLichen sclerosus
dc.subject.otherMucocutaneous diseases
dc.subject.otherOral mucosa
dc.titleOral lichen sclerosus: a rare case report and review of the literature
dc.typeArtigo de periódico
local.citation.epage218
local.citation.issue2
local.citation.spage212
local.citation.volume11
local.description.resumoLichen sclerosus (LS) is a chronic inflammatory mucocutaneous disease that often affects the anogenital area and causes significant discomfort and morbidity. Oral mucosal lesions in LS are extremely rare and might be associated with genital and/or skin manifestations. As a unique manifestation of LS, oral lesions are even more rare, with only 20 cases reported in English-language literature. In reviewing that literature in this paper, we present the case of a 44-year-old white man who sought dental assistance with a complaint of a white spot on his upper lip. Extraoral clinical examination revealed a slight white macule on the left upper lip vermilion next to the labial commissure. Intraoral examination revealed that the macule was approximately 3.5 × 2.0 cm, extended to the upper left labial mucosa, and presented an ivory-white color. Following an incisional biopsy and microscopy, the lesion was shown to be covered by a stratified squamous epithelium showing hyperkeratosis and atrophy. The superficial lamina propria revealed a well-marked band of subepithelial hyalinization and, below it, a band-like mononuclear inflammatory infiltrate. Sections stained by Verhoeff's technique revealed a scantiness of elastic fibers in the superficial lamina propria. The diagnosis of LS was then established. The patient was referred for dermatologic evaluation, which identified no skin or genital lesions, and no treatment was employed. After 6 years, no significant changes in clinical features were observed. Altogether, this rare case makes an important contribution to knowledge on this uncommon condition.
local.identifier.orcidhttps://orcid.org/0000-0002-9709-6795
local.identifier.orcidhttps://orcid.org/0000-0001-5166-1982
local.identifier.orcidhttps://orcid.org/0000-0001-7698-7532
local.identifier.orcidhttps://orcid.org/0000-0001-8770-8009
local.identifier.orcidttps://orcid.org/0000-0003-0176-0741
local.identifier.orcidhttps://orcid.org/0000-0003-0192-5614
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.initialsUFMG
local.url.externahttps://link.springer.com/article/10.1007/s12105-016-0766-x

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