Increased N200 and P300 latencies in cognitively impaired elderly carrying ApoE ε-4 allele

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dc.creatorMarco Túlio Gualberto Cintra
dc.creatorNilton Alves de Rezende
dc.creatorMaria Aparecida Camargos Bicalho
dc.creatorRafaela Ávila
dc.creatorThayana Oliveira Soares
dc.creatorLuciana Cristina Matos Cunha
dc.creatorKatia Daniela Silveira
dc.creatorEdgar Nunes Moraes
dc.creatorKaique Roger Simas
dc.creatorRenato Bragança Fernandes
dc.creatorDenise Utsch Gonçalves
dc.date.accessioned2023-08-07T20:49:59Z
dc.date.accessioned2025-09-09T01:19:59Z
dc.date.available2023-08-07T20:49:59Z
dc.date.issued2018
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1002/gps.4773
dc.identifier.issn0885-6230
dc.identifier.urihttps://hdl.handle.net/1843/57580
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofInternational Journal of Geriatric Psychiatry
dc.rightsAcesso Restrito
dc.subjectDoença de Alzheimer
dc.subjectApolipoproteínas E
dc.subjectPotenciais Evocados Auditivos
dc.subjectFator Neurotrófico Derivado do Encéfalo
dc.subjectDisfunção Cognitiva
dc.subject.otherAlzheimer' s disease
dc.subject.otherApolipoproteins E
dc.subject.otherAuditory evoked potentials
dc.subject.otherBrain-Derived Neurotrophic Factor
dc.subject.otherMild cognitive impairment
dc.titleIncreased N200 and P300 latencies in cognitively impaired elderly carrying ApoE ε-4 allele
dc.typeArtigo de periódico
local.citation.epagee227
local.citation.issue2
local.citation.spagee221
local.citation.volume33
local.description.resumoObjective: To compare the results of neuropsychological tests, evoked potentials N200 andP300 and polymorphisms of ApoE and BDNF rs6265 between patients with normal cognition and those with mild cognitive impairment (MCI) and Alzheimer's dementia (AD). Methods: This is a cross‐sectional study of elderly individuals with normal cognition and those with MCI and AD, who were submitted to evoked potential tests (N200 and P300) by means of hearing stimuli based on the auditory oddball paradigm. Genotyping was obtained by using the real‐time PCR technique.Results: Sixty‐five patients were evaluated as follows: 14 controls, 34 with MCI and 17 with AD. N200 latency and P300 latency and amplitude were not associated with MCI and AD diagnosis. Patients with cognitive impairment (MCI or AD) showed increase in the latencies of P300 and N200. BNDF gene was not associated with cognitive impairment.Conclusion: Latencies of N200 and P300 increased in cognitively impaired patients with the presence of ApoE ε‐4 allele.
local.identifier.orcidhttps://orcid.org/0000-0003-3089-655X
local.publisher.countryBrasil
local.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICA
local.publisher.initialsUFMG
local.url.externahttps://onlinelibrary.wiley.com/journal/10991166

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