Neighbor danger: Yellow fever virus epizootics in urban and urban-rural transition areas of Minas Gerais state, during 2017-2018 yellow fever outbreaks in Brazil

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dc.creatorLívia Sacchetto
dc.creatorRodolfo German Antonelli Vidal Stumpp
dc.creatorAlaine Izabela Alves Prado
dc.creatorAdriano Pereira Paglia
dc.creatorFernando Araújo Perini
dc.creatorMaurício Lacerda Nogueira
dc.creatorErna Geessien Kroon
dc.creatorBenoit de Thoisy
dc.creatorGiliane de Souza Trindade
dc.creatorBetânia Paiva Drumond
dc.creatorNatalia Ingrid Oliveira Silva
dc.creatorIzabela Maurício de Rezende
dc.creatorMatheus Soares Arruda
dc.creatorThais Alkifeles Costa
dc.creatorÉrica Munhoz de Mello
dc.creatorGabriela Fernanda Garcia Oliveira
dc.creatorPedro Augusto Alves
dc.creatorVítor Emídio de Mendonça
dc.date.accessioned2023-07-15T00:17:40Z
dc.date.accessioned2025-09-09T00:19:08Z
dc.date.available2023-07-15T00:17:40Z
dc.date.issued2020-10-05
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1371/journal.pntd.0008658
dc.identifier.issn1935-2735
dc.identifier.urihttps://hdl.handle.net/1843/56355
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofPLoS Neglected Tropical Diseases
dc.rightsAcesso Aberto
dc.subjectFebre Amarela
dc.subjectFebre amarela - Vacina
dc.subject.otherYellow Fever virus
dc.subject.otherYellow Fever
dc.subject.otherSurveillance
dc.titleNeighbor danger: Yellow fever virus epizootics in urban and urban-rural transition areas of Minas Gerais state, during 2017-2018 yellow fever outbreaks in Brazil
dc.typeArtigo de periódico
local.citation.epage16
local.citation.issue10
local.citation.spagee0008658
local.citation.volume14
local.description.resumoBackground From the end of 2016 until the beginning of 2019, Brazil faced a massive sylvatic yellow fever (YF) outbreak. The 2016–2019 YF epidemics affected densely populated areas, especially the Southeast region, causing thousands of deaths of humans and non-human primates (NHP). Methodology/Principal findings We conducted a molecular investigation of yellow fever virus (YFV) RNA in 781 NHP carcasses collected in the urban, urban-rural interface, and rural areas of Minas Gerais state, from January 2017 to December 2018. Samples were analyzed according to the period of sampling, NHP genera, sampling areas, and sampling areas/NHP genera to compare the proportions of YFV-positive carcasses and the estimated YFV genomic loads. YFV infection was confirmed in 38.1% of NHP carcasses (including specimens of the genera Alouatta, Callicebus, Callithrix, and Sapajus), from the urban, urban-rural interface, and rural areas. YFV RNA detection was positively associated with epidemic periods (especially from December to March) and the rural environment. Higher median viral genomic loads (one million times) were estimated in carcasses collected in rural areas compared to urban ones. Conclusions/Significance The results showed the wide occurrence of YF in Minas Gerais in epidemic and non-epidemic periods. According to the sylvatic pattern of YF, a gradient of viral dissemination from rural towards urban areas was observed. A high YF positivity was observed for NHP carcasses collected in urban areas with a widespread occurrence in 67 municipalities of Minas Gerais, including large urban centers. Although there was no documented case of urban/Aedes YFV transmission to humans in Brazil during the 2016–2019 outbreaks, YFV-infected NHP in urban areas with high infestation by Aedes aegypti poses risks for YFV urban/Aedes transmission and urbanization.
local.identifier.orcidhttps://orcid.org/0000-0002-4336-9284
local.publisher.countryBrasil
local.publisher.departmentICB - DEPARTAMENTO DE MICROBIOLOGIA
local.publisher.departmentICB - DEPARTAMENTO DE ZOOLOGIA
local.publisher.departmentICB - INSTITUTO DE CIÊNCIAS BIOLOGICAS
local.publisher.initialsUFMG
local.url.externahttps://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0008658

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