Hepatitis c in the brazilian public health care system: burden of disease

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dc.creatorAdautocastelo
dc.creatorPaulo Roberto Abrão Ferreira
dc.creatorCarlos Eduardo Brandão Mello
dc.creatorRosangela Teixeira
dc.creatorJose Valdez Ramalho Madruga
dc.creatorTania Reuter
dc.creatorLeila Maria Moreira Beltrão Pereira
dc.creatorGiovanni Faria Silva
dc.creatorMario Reis Álvares-da-silva
dc.creatorHeverton Zambrini
dc.date.accessioned2024-01-11T22:45:21Z
dc.date.accessioned2025-09-08T23:05:49Z
dc.date.available2024-01-11T22:45:21Z
dc.date.issued2018
dc.format.mimetypepdf
dc.identifier.doi10.1590/s0004-2803.201800000-74
dc.identifier.issn16784219
dc.identifier.urihttps://hdl.handle.net/1843/62661
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofArquivos de Gastroenterologia
dc.rightsAcesso Aberto
dc.subjectHepatitis C
dc.subjectLiver Cirrhosis
dc.subjectQuality of life.
dc.subjectCost of Illness
dc.subject.otherHepatitis C
dc.subject.otherLiver Cirrhosis
dc.subject.otherQuality of life.
dc.subject.otherCost of Illness
dc.titleHepatitis c in the brazilian public health care system: burden of disease
dc.typeArtigo de periódico
local.citation.epage337
local.citation.issue4
local.citation.spage329
local.citation.volume55
local.description.resumoBackground – Infection by hepatitis C virus is one of the leading causes of chronic hepatitis C and cause severe burden for patients, families and the health care system. Objective – The aims of this research were to assess the severity of liver fibrosis, comorbidities and complications of hepatitis C virus; to examine health-related quality of life (HRQoL), productivity loss and resource use and costs in a sample of Brazilian chronic hepatitis C, genotype 1, patients. Methods – This was a cross-sectional multicenter study performed in genotype-1 chronic hepatitis C patients to assess disease burden in the Brazilian public health care system between November 2014 and March 2015. Patients were submitted to a liver transient elastography (FibroScan) to assess liver fibrosis and answered an interview composed by a questionnaire specifically developed for the study and three standardized questionnaires: EQ-5D-3L, HCV-PRO and WPAI:HepC. Results – There were 313 subjects enrolled, with predominance of women (50.8%), caucasian/white (55.9%) and employed individuals (39.9%). Mean age was 56 (SD=10.4) years old. Moreover, 42.8% of patients who underwent FibroScan were cirrhotic; the most frequent comorbidity was cardiovascular disease (62.6%) and the most frequent complication was esophageal varices (54.5%). The results also showed that “pain and discomfort” was the most affected HRQoL dimension (55.0% of patients reported some problems) and that the mean HCV-PRO overall score was 69.1 (SD=24.2). Regarding productivity loss, the most affected WPAI:HepC component was daily activity (23.5%) and among employed patients, presenteeism was more frequent than absenteeism (18.5% vs 6.5%). The direct medical costs in this chronic hepatitis C sample was 12,305.72USD per patient in the 2 years study period; drug treatment costs represented 95.9% of this total. Conclusion – This study showed that most patients are cirrhotic, present high prevalence of cardiometabolic diseases and esophageal varices, reducedHRQoL mainly in terms of pain/discomfort, and work productivity impairment, especially presenteeism. Additionally, we demonstrated that hepatitis C virus imposes an economic burden on Brazilian Health Care System and that most of this cost is due to drug treatmen.
local.publisher.countryBrasil
local.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICA
local.publisher.initialsUFMG
local.url.externahttps://doi.org/10.1590/S0004-2803.201800000-74

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