Auditory stimulation by exposure to melodic music increases dopamine and serotonin activities in rat forebrain areas linked to reward and motor control

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dc.creatorMichele Macedo Moraes
dc.creatorPatrícia da Conceição Rocha Rabelo
dc.creatorValéria Andrade Pinto
dc.creatorWashington Pires
dc.creatorSamuel Penna Wanner
dc.creatorRaphael Escorsim Szawka
dc.creatorDanusa Dias Soares
dc.date.accessioned2023-02-01T14:58:36Z
dc.date.accessioned2025-09-09T00:40:56Z
dc.date.available2023-02-01T14:58:36Z
dc.date.issued2018-04
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.identifier.doihttps://doi.org/10.1016/j.neulet.2018.02.058
dc.identifier.issn0304-3940
dc.identifier.urihttps://hdl.handle.net/1843/49370
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofNeuroscience Letters
dc.rightsAcesso Restrito
dc.subjectGânglios da base
dc.subjectDopamina
dc.subjectAminas
dc.subjectMúsica
dc.subjectCérebro - Localização das funções
dc.subjectSerotonina
dc.subject.otherCaudate-putamen
dc.subject.otherDopamine
dc.subject.otherMonoamines
dc.subject.otherMusic
dc.subject.otherNucleus accumbens
dc.subject.otherSerotonin
dc.titleAuditory stimulation by exposure to melodic music increases dopamine and serotonin activities in rat forebrain areas linked to reward and motor control
dc.typeArtigo de periódico
local.citation.epage78
local.citation.spage73
local.citation.volume673
local.description.resumoListening to melodic music is regarded as a non-pharmacological intervention that ameliorates various disease symptoms, likely by changing the activity of brain monoaminergic systems. Here, we investigated the effects of exposure to melodic music on the concentrations of dopamine (DA), serotonin (5-HT) and their respective metabolites in the caudate-putamen (CPu) and nucleus accumbens (NAcc), areas linked to reward and motor control. Male adult Wistar rats were randomly assigned to a control group or a group exposed to music. The music group was submitted to 8 music sessions [Mozart’s sonata for two pianos (K. 488) at an average sound pressure of 65 dB]. The control rats were handled in the same way but were not exposed to music. Immediately after the last exposure or control session, the rats were euthanized, and their brains were quickly removed to analyze the concentrations of 5-HT, DA, 5-hydroxyindoleacetic acid (5-HIAA) and 3,4-dihydroxyphenylacetic acid (DOPAC) in the CPu and NAcc. Auditory stimuli affected the monoaminergic system in these two brain structures. In the CPu, auditory stimuli increased the concentrations of DA and 5-HIAA but did not change the DOPAC or 5-HT levels. In the NAcc, music markedly increased the DOPAC/DA ratio, suggesting an increase in DA turnover. Our data indicate that auditory stimuli, such as exposure to melodic music, increase DA levels and the release of 5-HT in the CPu as well as DA turnover in the NAcc, suggesting that the music had a direct impact on monoamine activity in these brain areas.
local.identifier.orcidhttps://orcid.org/0000-0003-4707-6099
local.identifier.orcidhttp://orcid.org/0000-0002-7313-6553
local.identifier.orcidhttps://orcid.org/0000-0003-3140-510X
local.identifier.orcidhttps://orcid.org/0000-0002-4659-1032
local.identifier.orcidhttps://orcid.org/0000-0002-2639-3469
local.identifier.orcidhttp://orcid.org/0000-0002-5705-8890
local.publisher.countryBrasil
local.publisher.departmentEEF - DEPARTAMENTO DE EDUCAÇÃO FÍSICA
local.publisher.departmentICB - DEPARTAMENTO DE FISIOLOGIA E BIOFÍSICA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S0304394018301460?via%3Dihub

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