Oral manifestations of Langerhans Cell histiocytosis: a case series

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dc.creatorRodrigo Neves-Silva
dc.creatorDiego Tetzner Fernandes
dc.creatorFelipe Paiva Fonseca
dc.creatorHélder Antônio Rebelo Pontes
dc.creatorBernardo Ferreira Brasileiro
dc.creatorAlan Roger dos Santos-Silva
dc.creatorPablo Agustin Vargas
dc.creatorMárcio Ajudarte Lopes
dc.date.accessioned2023-10-27T18:55:11Z
dc.date.accessioned2025-09-09T00:10:22Z
dc.date.available2023-10-27T18:55:11Z
dc.date.issued2018
dc.identifier.doihttps://doi.org/10.1111/scd.12330
dc.identifier.issn02751879
dc.identifier.urihttps://hdl.handle.net/1843/60178
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofSpecial Care in Dentistry
dc.rightsAcesso Restrito
dc.subjectHistiocytosis, Langerhans-Cell
dc.subjectOral manifestations
dc.subjectOral medicine
dc.subjectMucous membrane
dc.subjectUlcer
dc.subject.otherOral manifestations of langerhans cell histiocytosis: a case series restrito busca dia 14 do 09 2023 fao clinica assunto Histiocytosis, Langerhans-Cell
dc.titleOral manifestations of Langerhans Cell histiocytosis: a case series
dc.typeArtigo de periódico
local.citation.epage433
local.citation.issue6
local.citation.spage426
local.citation.volume38
local.description.resumoAim: Langerhans cell histiocytosis (LCH) is an unusual proliferative disorder of bone marrow-derived histiocytes (Langerhans cells) that can produce focal or systemic manifestations. Oral manifestations of LCH can present as single or multiple lesions and can be a challenge in clinical practice. The aim of this paper is to present the clinicopathological features of a series of nine patients with oral involvement. Methods and results: The patient's age ranged from 2 to 63 years being five males and four females. The most common oral site involvement was the hard-palate mucosa. Ulceration was the main clinical feature. Only two patients showed clearly jawbone involvement. In eight out of nine patients, the diagnosis of LCH was established because of the oral manifestations. Conclusion: The recognition of the clinical features of LCH oral manifestation is important to avoid misdiagnosis and to the establishment of the correct treatment. Thus, dentists can play a vital role in the diagnosis of LCH since oral lesions may be the earliest manifestation and sometimes the only sign of the disease. Furthermore, oral lesions may be the early signs of disease reactivation or a multisystem disease indication.
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.initialsUFMG
local.url.externahttps://onlinelibrary.wiley.com/doi/10.1111/scd.12330

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