Immunological signatures in saliva of systemic lupus erythematosus patients: influence of periodontal condition

Página do item simplificado
dc.creatorSantuza Maria Souzamendonça
dc.creatorTarcília Aparecida da Silva
dc.creatorJôice Dias Corrêa
dc.creatorAlessandra Figueiredo de Souza
dc.creatorDenise v. Travassos
dc.creatorDébora Cerqueira Calderaro
dc.creatorÉrica Leandro Marciano Vieira
dc.creatorAntônio Lúcio Teixeira
dc.creatorGilda Aparecida Ferreira
dc.creatorNatália Pessoa Rocha
dc.date.accessioned2023-07-20T21:39:56Z
dc.date.accessioned2025-09-08T22:59:18Z
dc.date.available2023-07-20T21:39:56Z
dc.date.issued2018-05-14
dc.format.mimetypepdf
dc.identifier.issn0392856X
dc.identifier.urihttps://hdl.handle.net/1843/56821
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofClinical and Experimental Rheumatology
dc.rightsAcesso Aberto
dc.subjectLúpus Eritematoso Sistêmico
dc.subjectPeriodontite Crônica
dc.subjectCitocinas
dc.subjectSaliva
dc.subject.othersystemic lupus erythematosus
dc.subject.otherChronic periodontitis
dc.subject.otherCytokine
dc.subject.otherSaliva
dc.titleImmunological signatures in saliva of systemic lupus erythematosus patients: influence of periodontal condition
dc.typeArtigo de periódico
local.citation.epage214
local.citation.spage208
local.citation.volume37
local.description.resumoThe immune system has an important role in the development of systemic lupus erythematosus (SLE) and chronic periodontitis (CP). Altered cytokines levels characterise both diseases and contributes to periodontal tissue damage in CP and to macrocomplexes deposition with connective tissue destruction in SLE. This study aimed to evaluate the production of salivary cytokines in patients with SLE and its association with periodontal status. The sample comprised 70 SLE patients and 70 paired controls. SLE activity and damage were scored using Systemic Lupus Erythematosus Disease Activity Index 2000 and Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index. Subjects were classified as without or with CP. Salivary concentrations of IL-33, MMP2/TIMP2, RANK and OPG were measured by ELISA, while IL-2, IFNγ, TNFα, IL-4, IL-6, IL-10 and IL-17A were determined by Cytometric Bead Array. Linear regression models analysed association among SLE, CP and salivary cytokines.IL-6 and IL-17A concentrations were significantly higher in SLE/CP patients than controls/CP. Concentrations of IL-6, IL-17A and IL-33 were increased in SLE/CP individuals when compared to SLE without CP. Multivariate model revealed association of cumulative dose of corticoids with periodontal damage and of IL-33 salivary concentration with SLE activity.Our findings suggest that long-term therapy with corticoids would contribute with periodontal destruction in SLE patients. Moreover, the increased levels of IL-6, IL-17A and IL-33 in saliva of SLE subjects with CP may signal it as possible inflammatory pathways in this process.
local.publisher.countryBrasil
local.publisher.departmentMED - DEPARTAMENTO DE APARELHO LOCOMOTOR
local.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICA
local.publisher.initialsUFMG

Arquivos

Pacote original

Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
Immunological signatures in saliva of systemic lupus erythematosus patients influence of periodontal condition pdfa.pdf
Tamanho:
475.92 KB
Formato:
Adobe Portable Document Format
Baixar

Licença do pacote

Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
License.txt
Tamanho:
1.99 KB
Formato:
Plain Text
Descrição:
Baixar

Coleções

Artigo de Periódico

Logo UFMG