Evaluation of mesalazine polymeric conjugate in the treatment of actinic proctitis in rats

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dc.creatorVinícius Rodrigues Tarantonunes
dc.creatorIvana Duval-araujo
dc.creatorPaula Vieira Teixeira Vidigal
dc.creatorMárcio Tadeu Pereira
dc.creatorLuís Carlos Duarte Ladeira
dc.creatorMarcelo Vidigal Caliari
dc.creatorFabrício Marcus Silva Oliveira
dc.creatorAina Liz Alves Cesar
dc.creatorAndré Augusto Gomes Faraco
dc.creatorRafael Calvão Barbuto
dc.date.accessioned2023-06-05T19:22:19Z
dc.date.accessioned2025-09-09T00:17:07Z
dc.date.available2023-06-05T19:22:19Z
dc.date.issued2021-07-24
dc.format.mimetypepdf
dc.identifier.doi10.1590/acb360805
dc.identifier.issn16782674
dc.identifier.urihttps://hdl.handle.net/1843/54520
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofActa Cirúrgica Brasileira
dc.rightsAcesso Aberto
dc.subjectRadioterapia
dc.subjectProctite
dc.subjectMesalamina
dc.subjectCondroitina
dc.subjectInflamação
dc.subjectRatos
dc.subject.otherRadiotherapy
dc.subject.otherProctitis
dc.subject.otherMesalamine
dc.subject.otherChondroitin
dc.subject.otherInflammation
dc.subject.otherRats
dc.titleEvaluation of mesalazine polymeric conjugate in the treatment of actinic proctitis in rats
dc.typeArtigo de periódico
local.citation.epage7
local.citation.issue8
local.citation.spage1
local.citation.volume36
local.description.resumoPurpose: The present study aimed at testing a new formulation of mesalazine linked to chondroitin sulfate and its components alone in the treatment of actinic proctitis in rats. Methods: Forty-seven female Wistar rats were submitted to pelvic radiation and divided into eight groups: control A, mesalazine A, chondroitin A, and conjugate A, gavage of the according substance two weeks after irradiation and sacrifice three weeks after oral treatment; control C, mesalazine C, chondroitin C, and conjugate C, sacrifice six weeks after oral treatment. The rectum was submitted to histological characterization for each of the findings: inflammatory infiltrate, epithelial degeneration, mucosal necrosis, and fibrosis. Results: The inflammatory infiltrate was more intense in chondroitin A, mesalazine A, and conjugate C. The collagen deposition was less intense in chondroitin A, and mesalazine A, and more intense in control C. Conclusion: Mesalazine and chondroitin alone were efficacious in inducing a delayed inflammatory response, hence reducing the late fibrosis. The conjugate was able to induce an ever more delayed inflammatory response.
local.identifier.orcidhttps://orcid.org/0000-0001-6488-734X
local.publisher.countryBrasil
local.publisher.departmentICB - DEPARTAMENTO DE PATOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://www.scielo.br/j/acb/a/Vfrcn7vM34HBV3MYrvZnJ7h/?lang=en

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