Acute lymphoblastic leukemia/lymphoma of the oral and maxillofacial region

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dc.creatorCeleste Sánchez-Romero
dc.creatorHélder Antônio Rebelo Pontes
dc.creatorFlávia Sirotheau Corrêa Pontes
dc.creatorAndré Caroli Rocha
dc.creatorRomán Carlos
dc.creatorJavier Rendon
dc.creatorOslei Paes de Almeida
dc.creatorFelipe Paiva Fonseca
dc.date.accessioned2023-10-24T18:45:51Z
dc.date.accessioned2025-09-09T01:32:57Z
dc.date.available2023-10-24T18:45:51Z
dc.date.issued2018-08
dc.identifier.doihttps://www.sciencedirect.com/science/article/pii/S2212440318300464?via%3Dihub
dc.identifier.issn22124403
dc.identifier.urihttps://hdl.handle.net/1843/59950
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofOral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
dc.rightsAcesso Restrito
dc.subjectLeukemia
dc.subjectLymphoma
dc.subjectImmunohistochemistry
dc.subjectPathology, oral
dc.subject.otheracesso restrito Acute lymphoblastic leukemia/lymphoma of the oral and maxillofacial region busca dia 11 do 09 2023 assunto leucemia, linfoma fao clínica
dc.titleAcute lymphoblastic leukemia/lymphoma of the oral and maxillofacial region
dc.typeArtigo de periódico
local.citation.epage164
local.citation.issue2
local.citation.spage152
local.citation.volume126
local.description.resumoObjective: Our objective was to describe the clinicopathologic and immunohistochemical features of acute lymphoblastic leukemia/lymphoma (ALL/LBL) of the oral and maxillofacial region (OMF). Study design: Cases diagnosed as ALL/LBL of the OMF region were retrieved from the files of 2 Brazilian and 1 Guatemalan oral pathology services from 2005 to 2017. Microscopic and immunohistochemical features of each case were reviewed and fully described, and clinical data were retrieved from the pathology reports. Results: During the period considered, 6 cases were identified. Male patients were the most affected (4:2), with a mean age of 19 years old. The mandible was involved in 2 cases, the maxilla in 2, the cheek mucosa in 1, and the parotid gland in 1. Painful swelling was the most common presentation, and 3 patients also had systemic complaints. Microscopically, tumors revealed solid infiltrations of small to medium-sized immature cells. "Puzzle-like" and "starry-sky" patterns were observed, and "single lane" growth was also identified. Immunohistochemically, 2 cases were diagnosed as T-cell ALL/LBL with the leukocyte common antigen (LCA)+/cCD3+/CD79 a+focal/CD20-/PAX5-/CD99+/CD34-/CD10+/terminal deoxynucleotidyl transferase (TdT)+ phenotype and 4 as B-cell ALL/LBL with the LCA+/CD3-/CD20-/CD79 a+/CD10+/CD34 variable/TdT+ predominant phenotype. The Ki67 index ranged from 80% to 99%. Conclusion: OMF ALL/LBL is rare, but its microscopic features and immunohistochemical profiles CD3+or CD79 a+/CD10+/CD34+variable/CD99+/TdT+ contribute to the correct diagnosis.
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.initialsUFMG
local.url.externahttps://doi.org/10.1016/j.oooo.2018.01.010

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