Development of a new model of actinic enteritis in rats using a cobalt-60 open source and a protection device as a collimator

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dc.creatorVinícius Rodrigues Taranto Nunes
dc.creatorPaula Vieira Teixeira Vidigal
dc.creatorMárcio Tadeu Pereira
dc.creatorLuís Carlos Duarte Ladeira
dc.creatorRafael Calvão Barbuto
dc.creatorIvana Duval-araujo
dc.date.accessioned2023-06-02T20:54:11Z
dc.date.accessioned2025-09-08T23:53:49Z
dc.date.available2023-06-02T20:54:11Z
dc.date.issued2017
dc.format.mimetypepdf
dc.identifier.doi10.1590/s0102-865020170040000007
dc.identifier.issn01028650
dc.identifier.urihttps://hdl.handle.net/1843/54419
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofActa Cirúrgica Brasileira
dc.rightsAcesso Aberto
dc.subjectRadioterapia
dc.subjectRadiação
dc.subjectEnterite
dc.subjectInflamação
dc.subjectFibrose
dc.subjectRatos
dc.subject.otherRadiotherapy
dc.subject.otherRadiation
dc.subject.otherEnteritis
dc.subject.otherInflammation
dc.subject.otherFibrosis
dc.subject.otherRats
dc.titleDevelopment of a new model of actinic enteritis in rats using a cobalt-60 open source and a protection device as a collimator
dc.typeArtigo de periódico
local.citation.epage324
local.citation.issue3
local.citation.spage319
local.citation.volume32
local.description.resumoPurpose: To describe a new model of actinic enteritis that does not use radiotherapy machines. Methods: Sixteen Wistar rats were divided into four groups, consisting of four animals each: control (group A), two weeks after irradiation (group B), five weeks after irradiation (groupC) and eight weeks after irradiation (group D). Animals were given a 10Gy radiation from a Cobalt-60 natural source in a nuclear technology research center. Protections of the surrounding tissues were obtained through the usage of plumb devices with a hole in the center, which served as a collimator. We obtained irradiated and non-irradiated colons from each animal. Results: In group B we found an important inflammatory response in the irradiated colon, which appeared in a reduced way in group C and was minimal in group D, in which we found a relevant collagen submucosal deposition/fibrosis. In all groups, the non-irradiated colon had a lower pathological damage in comparison with the irradiated colon.Conclusion: We thus described an efficient and feasible technique for obtaining an animal model of actinic enteritis.
local.identifier.orcidhttps://orcid.org/0000-0001-6488-734X
local.publisher.countryBrasil
local.publisher.departmentMED - DEPARTAMENTO DE ANATOMIA PATOLÓGICA E MEDICINA LEGAL
local.publisher.departmentMED - DEPARTAMENTO DE CIRURGIA
local.publisher.initialsUFMG
local.url.externahttp://dx.doi.org/10.1590/s0102-865020170040000007

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