A meta-analysis on the effect of periodontal treatment on the glomerular filtration rate of chronic kidney disease individuals
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Universidade Federal de Minas Gerais
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Artigo de periódico
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Membros da banca
Resumo
Aims: The purpose of the present systematic review and meta-analysis wasto assess the impact of periodontal treatment on the glomerular filtration rate(GFR) of individuals with chronic kidney disease (CKD).Methods: Searches were conducted in five databases. Restrictions on publica-tion date or language were not imposed. Studies reporting the GFR of CKD indi-viduals before and after periodontal treatment were included. Studies’ selection,extraction of data and assessment of risk of bias were performed by two review-ers independently. The Methodological Index for non-randomized studies wasemployed for risk of bias assessment. Meta-analysis was carried out.Results: One hundred ninety-two references were retrieved and three studieswere included. In all studies included, the periodontal intervention performedwas non-surgical therapy. The three studies together assessed 77 individuals.The follow-up of participants after periodontal treatment varied between 3 and6 months. Meta-analysis demonstrated that the GFR of individuals with CKDincreased (improvement) after periodontal treatment (mean difference = 7.01,confidence interval = 0.66 – 13.36, I 2 = 0%). Overall, included studies presentedlow risk of bias.Conclusion: Despite the limited evidence of this systematic review and meta-analysis, periodontal treatment seems to improve the GFR of CKD individuals,with positive repercussions on their renal function.
Abstract
Assunto
Glomerular filtration rate, Renal insufficiency, chronic, Meta-analysis, Therapeutics, Periodontitis, Systematic review, Disease
Palavras-chave
Chronic kidney, Glomerular filtration rate, Meta-analysis, Periodontal treatment, Periodontitis, Systematic review disease
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https://onlinelibrary.wiley.com/doi/10.1111/scd.12625?msockid=0316d60ee8df68442d38c2f0e97469cf