Pulmonary function in former very low birth weight preterm infants in the first year of life

dc.creatorDaniela de Melo Miranda Gonçalves
dc.creatorGustavo Falbo Wandalsen
dc.creatorAna Sílvia Scavacini
dc.creatorFernanda de Córdoba Lanza
dc.creatorAna Lucia Goulart
dc.creatorDirceu Solé
dc.creatorAmélia Miyashiro Nunes dos Santos
dc.date.accessioned2022-12-21T14:52:08Z
dc.date.accessioned2025-09-08T22:51:26Z
dc.date.available2022-12-21T14:52:08Z
dc.date.issued2018-03
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1016/j.rmed.2018.02.004
dc.identifier.issn0954-6111
dc.identifier.urihttps://hdl.handle.net/1843/48304
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofRespiratory Medicine
dc.rightsAcesso Aberto
dc.subjectRecém-nascido
dc.subjectPrematuros
dc.subjectPulmões - Fisiologia
dc.subjectPletismografia
dc.subjectFatores de risco
dc.subject.otherChild
dc.subject.otherInfant
dc.subject.otherPremature
dc.subject.otherPulmonary function
dc.subject.otherPlethysmography
dc.subject.otherRisk factors
dc.titlePulmonary function in former very low birth weight preterm infants in the first year of life
dc.typeArtigo de periódico
local.citation.epage87
local.citation.spage83
local.citation.volume136
local.description.resumoBackground: Pulmonary function in former preterm infants may be compromised during childhood. Objectives: To assess pulmonary function in very-low-birth-weight preterm infants at 6–12 months of corrected age and analyze the factors associated with abnormal pulmonary function. Methods: Cross-sectional study with preterm infants at 6–12 months of corrected age with birth weight <1500 g. Children with malformations or affected by neuromuscular and respiratory diseases were excluded. Forced expiratory flows were assessed using the chest compression technique, and volumes were measured by total body plethysmography. Pulmonary function parameters in preterm infants were compared to a control group of same-aged children born at term. Results: We studied 51 preterm and 37 infants born at term. Preterm infants had: gestational age at birth (30.0 ± 2.5 weeks), birth weight (1179 ± 247 g), 27.5% had bronchopulmonary dysplasia, and 45% received mechanical ventilation. Preterm infants had lower median z-scores in comparison to term infants for the following parameters (p < 0.05): FVC (−0.3 vs. 0.7), FEV0.5 (−0.5 vs. 0.9), FEV0.5/FVC (−0.6 vs. −0.5), FEF50 (−0.4 vs. 0.9), FEF75 (−0.3 vs. 0.8), FEF85 (−0.1 vs. 0.6) and FEF25-75 (−0.5 vs. 1.1). No term child had abnormal lung function, compared to 39.2% of preterm infants (p = 0.001). Factors associated with abnormal pulmonary function were lower gestational age at birth, small for gestational age, need for mechanical ventilation and presence of recurrent wheezing. Conclusions: Preterms had a high prevalence of abnormal pulmonary function and lower pulmonary function in comparison to term infants. Prematurity, intrauterine growth restriction, respiratory support and recurrent wheezing were associated with abnormal pulmonary function.
local.identifier.orcidhttps://orcid.org/0000-0001-5243-2436
local.identifier.orcidhttp://orcid.org/0000-0003-2173-4380
local.identifier.orcidhttps://orcid.org/0000-0001-9845-6097
local.identifier.orcidhttps://orcid.org/0000-0002-4748-6947
local.identifier.orcidhttps://orcid.org/0000-0002-3579-0861
local.identifier.orcidhttp://orcid.org/0000-0002-8407-1556
local.publisher.countryBrasil
local.publisher.departmentEEF - DEPARTAMENTO DE FISIOTERAPIA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S0954611118300337?via%3Dihub

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