Exploring the DNA binding, oxidative cleavage, and cytotoxic properties of new ternary copper(II) compounds containing 4-aminoantipyrine and N,N-heterocyclic co-ligands

Página do item simplificado
dc.creatorÍvina Paula de Souza
dc.creatorBárbara de Paiva Machado
dc.creatorAlexandre Bizzotto de Carvalho
dc.creatorIldefonso Binatti
dc.creatorKlaus Wilhelm Heinrich Krambrock
dc.creatorZara Molphy
dc.creatorAndrew Kellett
dc.creatorElene Cristina Pereira Maia
dc.creatorPriscila Pereira Silva Caldeira
dc.date.accessioned2022-11-10T13:18:39Z
dc.date.accessioned2025-09-09T01:24:23Z
dc.date.available2022-11-10T13:18:39Z
dc.date.issued2018
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.identifier.doihttps://doi.org/10.1016/j.molstruc.2018.10.004
dc.identifier.issn00222860
dc.identifier.urihttps://hdl.handle.net/1843/47119
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Molecular Structure
dc.rightsAcesso Restrito
dc.subjectDNA
dc.subject.other4-aminoantipyrine
dc.subject.otherCopper(II) complex
dc.subject.otherAntitumoral activity
dc.subject.otherTopoisomerase
dc.titleExploring the DNA binding, oxidative cleavage, and cytotoxic properties of new ternary copper(II) compounds containing 4-aminoantipyrine and N,N-heterocyclic co-ligands
dc.typeArtigo de periódico
local.citation.epage28
local.citation.spage18
local.citation.volume1178
local.description.resumoHerein we report on the synthesis and characterization of new water-soluble complexes with the basic formula [Cu(OeN)(NeN)(ClO4)2], where OeN ¼ 4-aminoantipyrine and NeN ¼ 1,10-phenanthroline (1) or 2,2ʹ-bipyridine (2). Both complexes have distorted tetragonal geometry around each copper centre, which is coordinated to both bidentate ligands in equatorial sites with two perchlorate ions weakly bonded in the axial positions. The compounds bind to DNA and induce oxidative DNA damage mediated by reactive oxygen species (ROS). Both complexes inhibit the growth of K562 cells in a concentration-dependent manner with IC50 values lower than the corresponding free ligands. Significantly, the most cytotoxic agent (complex 1) presented high in vitro nucleolytic activity by generating single- and double-strand breaks, besides of inhibiting topoisomerase I enzymatic activity at low micromolar concentration.
local.identifier.orcidhttps://orcid.org/0000-0002-8699-6165
local.identifier.orcidhttps://orcid.org/0000-0002-0454-0026
local.identifier.orcidhttps://orcid.org/0000-0002-7562-0285
local.identifier.orcidhttps://orcid.org/0000-0001-9717-6130
local.identifier.orcidhttps://orcid.org/0000-0002-8947-1401
local.identifier.orcidhttps://orcid.org/0000-0003-2699-6232
local.identifier.orcidhttps://orcid.org/0000-0002-9983-3840
local.publisher.countryBrasil
local.publisher.departmentICX - DEPARTAMENTO DE FÍSICA
local.publisher.departmentICX - DEPARTAMENTO DE QUÍMICA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S0022286018311815

Arquivos

Licença do pacote

Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
License.txt
Tamanho:
1.99 KB
Formato:
Plain Text
Descrição:
Baixar

Coleções

Artigo de Periódico

Logo UFMG