Antiviral activity of Fridericia formosa (Bureau) L. G. Lohmann (Bignoniaceae) extracts and constituents

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dc.creatorGeraldo Célio Brandão
dc.creatorErna Geessien Kroon
dc.creatorJosé Souza Filho
dc.creatorAlaíde Braga Oliveira
dc.date.accessioned2025-02-07T21:07:10Z
dc.date.accessioned2025-09-08T23:19:43Z
dc.date.available2025-02-07T21:07:10Z
dc.date.issued2017-05-29
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1155/2017/6106959
dc.identifier.issn1687-9686
dc.identifier.urihttps://hdl.handle.net/1843/79769
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Tropical Medicine
dc.rightsAcesso Aberto
dc.subjectBignoniacea
dc.subjectAgentes antivirais
dc.subjectVírus da dengue
dc.subjectHerpesvírus
dc.subject.otherBignoniacea
dc.subject.otherAgentes antivirais
dc.titleAntiviral activity of Fridericia formosa (Bureau) L. G. Lohmann (Bignoniaceae) extracts and constituents
dc.typeArtigo de periódico
local.citation.epage11
local.citation.spage1
local.citation.volume2017
local.description.resumoA phytochemical study of Fridericia formosa (Bignoniaceae) ethanol extracts of leaves, stems, and fruits was guided by in vitro assays against vaccinia virus Western Reserve (VACV-WR), human herpes virus 1 (HSV-1), murine encephalomyocarditis virus (EMCV), and dengue virus type 2 (DENV-2) by the MTT method. All the ethanol extracts were active against DENV-2, HSV-1, and VACV-WR with best results for the fruits extract against DENV-2 (SI > 38.2). For VACV-WR and HSV-1, EC50 values > 200 μg mL−1 were determined, while no inhibition of the cytopathic effect was observed with EMCV. Five compounds were isolated and identified as the C-glucosylxanthones mangiferin (1), 2′-O-trans-caffeoylmangiferin (2), 2′-O-trans-coumaroylmangiferin (3), 2′-O-trans-cinnamoylmangiferin (5), and the flavonoid chrysin (4). The most active compound was 2′-O-trans-coumaroylmangiferin (3) with SI > 121.9 against DENV-2 and 108.7 for HSV-1. These results indicate that mangiferin cinnamoyl esters might be potential antiviral drugs.
local.identifier.orcidhttps://orcid.org/0000-0002-7330-051X
local.identifier.orcidhttps://orcid.org/0000-0003-2721-3826
local.publisher.countryBrasil
local.publisher.departmentICB - DEPARTAMENTO DE MICROBIOLOGIA
local.publisher.departmentICX - DEPARTAMENTO DE QUÍMICA
local.publisher.initialsUFMG
local.url.externahttps://onlinelibrary.wiley.com/doi/epdf/10.1155/2017/6106959

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