Phase behavior of dioleyphosphatidylethanolamine molecules in the presence of components of pH-sensitive liposomes and paclitaxel

Página do item simplificado
dc.creatorLiziane Oliveira Fonseca Monteiro
dc.creatorSávia Caldeira de Araújo Lopes
dc.creatorAndré Luís Branco de Barros
dc.creatorRogério Magalhães Paniago
dc.creatorÂngelo Malachias de Souza
dc.creatorMônica Cristina de Oliveira
dc.creatorElaine Amaral Leite
dc.date.accessioned2023-04-04T13:01:50Z
dc.date.accessioned2025-09-08T23:59:10Z
dc.date.available2023-04-04T13:01:50Z
dc.date.issued2016
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.identifier.doihttps://doi.org/10.1016/j.colsurfb.2016.04.011
dc.identifier.issn1873-4367
dc.identifier.urihttps://hdl.handle.net/1843/51534
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofColloids and Surfaces B: Biointerfaces
dc.rightsAcesso Restrito
dc.subjectCalorimetria
dc.subjectCâncer
dc.subjectTransição de fase
dc.subject.otherPaclitaxel
dc.subject.otherPH-sensitive liposomes
dc.subject.otherDioleylphosphatidylethanolamine
dc.subject.otherDifferential scanning calorimetry
dc.subject.otherSmall angle X-ray scattering
dc.subject.otherCancer
dc.subject.otherPhase transition
dc.titlePhase behavior of dioleyphosphatidylethanolamine molecules in the presence of components of pH-sensitive liposomes and paclitaxel
dc.typeArtigo de periódico
local.citation.epage283
local.citation.spage276
local.citation.volume144
local.description.resumoPaclitaxel is a potent antimicrotubule chemotherapeutic agent widely used for clinical treatment of a variety of solid tumors. However, the low solubility of the drug in aqueous medium and the toxic effects of the commercially available formulation, Taxol®, has hindered its clinical application. To overcome these paclitaxel-related disadvantages, several drug delivery approaches have been thoroughly investigated. In this context, our research group has developed long-circulating and pHsensitive liposomes containing paclitaxel composed of dioleylphosphatidylethanolamine, cholesterylhemisuccinate and distearoylphosphatidylethanolamine-polyethylene glycol2000, which have shown to be very promising carriers for this taxane. For the destabilization of pH-sensitive liposomal systems and the release of the encapsulated drug in the cytoplasm of tumor cells, the occurrence of a phase transition from a lamellar to a non-lamellar phase of dioleylphosphatidylethanolamine molecules is essential. Two techniques, differential scanning calorimetry and small angle X-ray scattering, were used to investigate the influence of the liposomal components and paclitaxel in the phase transition process of dioleylphosphatidylethanolamine molecules and to evaluate the pH-sensitivity of the formulation under low hydration conditions. The findings clearly evidence the phase transition of dioleylphosphatidylethanolamine molecules in the presence and absence of PTX indicating that the introduction of the drug in the system does not bring damage to the pH-sensitivity of the system, which resulting in liposome destabilization at low pH regions and encapsulated paclitaxel release preferentially in a desired target tissue.
local.identifier.orcidhttps://orcid.org/0000-0001-7808-0838
local.identifier.orcidhttps://orcid.org/0000-0002-7641-6585
local.identifier.orcidhttps://orcid.org/0000-0002-5203-0944
local.identifier.orcidhttps://orcid.org/0000-0001-8812-3811
local.publisher.countryBrasil
local.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS
local.publisher.departmentFAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOS
local.publisher.departmentICX - DEPARTAMENTO DE FÍSICA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S0927776516302685?via%3Dihub

Arquivos

Licença do pacote

Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
License.txt
Tamanho:
1.99 KB
Formato:
Plain Text
Descrição:
Baixar

Coleções

Artigo de Periódico

Logo UFMG