Oral gallic acid improve liver steatosis and metabolism modulating hepatic lipogenic markers in obese mice

Página do item simplificado
dc.creatorJaciara Neves Sousa
dc.creatorAlanna Fernandes Paraíso
dc.creatorJoão Marcus Oliveira Andrade
dc.creatorDeborah Farias Lelis
dc.creatorEloa Mangabeira Santos
dc.creatorJuliana Pinto Lima
dc.creatorRenato Sobral Monteiro Júnior
dc.creatorMarcos Flávio Silveira Vasconcelos D'Angelo
dc.creatorAlfredo Maurício Batista de Paula
dc.creatorAndré Luiz Sena Guimarães
dc.creatorSergio Henrique Sousa Santos
dc.date.accessioned2022-08-31T14:43:18Z
dc.date.accessioned2025-09-08T23:12:17Z
dc.date.available2022-08-31T14:43:18Z
dc.date.issued2020-06
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.identifier.doihttps://doi.org/10.1016/j.exger.2020.110881
dc.identifier.issn0531-5565
dc.identifier.urihttps://hdl.handle.net/1843/44767
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofExperimental Gerontology
dc.rightsAcesso Restrito
dc.subjectEsteatose hepática
dc.subjectObesidade
dc.subjectBioinformática
dc.subjectÁcido gálico
dc.titleOral gallic acid improve liver steatosis and metabolism modulating hepatic lipogenic markers in obese mice
dc.typeArtigo de periódico
local.citation.spage110881
local.citation.volume134
local.description.resumoIntroduction: gallic acid (GA) is a natural endogenous polyphenol found in a variety of fruits, vegetables and wines, with beneficial effects on the energetic homeostasis. Aim: the present study aimed to investigate oral gallic acid effects on liver steatosis and hepatic lipogenesis markers in obese mice evaluating new possible molecular related mechanisms. Methods: twenty-four Swiss male mice were divided into four groups and fed for 60 days with standard diet (ST), standard diet plus gallic acid (ST + GA), high-fat diet (HFD), and high-fat diet plus gallic acid (HFD + GA). We evaluated the relationship between body weight, food intake and serum levels of total cholesterol, triglycerides, insulin, aspartate and alanine transaminases. Liver histology was analyzed by hematoxylin and eosin staining. These results were accompanied by bioinformatics analyses. The acetyl-CoA carboxylase (ACC), sterol regulatory element binding protein-1 (SREBP-1) and fatty acid synthase (FAS) expression was assessed by quantitative real-time reverse transcriptase PCR (qRT-PCR). Results: the main findings of the present study showed that GA reduced liver steatosis, body weight and plasma insulin levels. Analyzes of hepatic steatosis related genes expression showed that ACC and FAS mRNA were significantly suppressed in liver of HFD + GA mice. These data was corroborated by bioinformatics analysis. Conclusion: these data suggest an important clinical application of GA in the prevention and treatment of liver diseases.
local.publisher.countryBrasil
local.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S0531556519307971?via%3Dihub

Arquivos

Licença do pacote

Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
License.txt
Tamanho:
1.99 KB
Formato:
Plain Text
Descrição:
Baixar

Coleções

Artigo de Periódico

Logo UFMG