Gorham-stout disease with involvement of the jaws: a systematic review

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dc.creatorBruno Ramos Chrcanovic
dc.creatorRicardo Santiago Gomez
dc.date.accessioned2024-11-26T20:50:56Z
dc.date.accessioned2025-09-08T22:49:14Z
dc.date.available2024-11-26T20:50:56Z
dc.date.issued2019
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1016/j.ijom.2019.03.002
dc.identifier.issn1399-0020
dc.identifier.urihttps://hdl.handle.net/1843/78298
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofInternational Journal of Oral and Maxillofacial Surgery
dc.rightsAcesso Restrito
dc.subjectOsteolysis, essential
dc.subjectJaw
dc.subjectTherapeutics
dc.subjectSigns and symptoms
dc.subjectFracture healing
dc.subjectPathology
dc.subjectWounds and injuries
dc.subjectAlkaline phosphatase
dc.subjectSystematic review
dc.subject.otherGorham–Stout disease
dc.subject.otherMassive osteolysis
dc.subject.otherJaw
dc.subject.otherClinical features
dc.subject.otherTreatment
dc.subject.otherPersistence following treatment
dc.titleGorham-stout disease with involvement of the jaws: a systematic review
dc.typeArtigo de periódico
local.citation.epage1021
local.citation.issue8
local.citation.spage1015
local.citation.volume48
local.description.resumoThe purpose of this study was to systematically review all published cases of Gorham–Stout disease (GSD) involving the jaws and to identify the clinico-radiological and histopathological features associated with persistence of the lesions, as well as the best treatment options available. An electronic search was undertaken in November 2018. Eligibility criteria included publications with sufficient information to confirm the diagnosis. Eighty-six publications reporting 89 cases were included. Features observed included symptomatic disease (51.1%), swelling (34.1%), pathological fracture (31.8%), history of previous trauma (32.1%), high alkaline phosphatase levels (24.3%), and predominance of vascular tissue (72.4%). Nearly a quarter of the patients were only followed up, with no treatment implemented. Most treatments consisted of some type of surgery with/without additional therapies (42.0%), drugs (20.5%), and radiotherapy (14.8%). Half of the cases were found to persist after some treatment modality, and five patients died. Among the variables investigated, only a lesion crossing the midline showed an association with persistence of the disease. There remains much to understand about GSD, a rare condition with no clear consensus on the aetiopathology, an unpredictable clinical course, and no standard treatment. The high rate of persistence after treatment was found to be associated only with the lesion crossing the midline.
local.identifier.orcidhttps://orcid.org/0000-0001-8770-8009
local.identifier.orcidhttps://orcid.org/0000-0002-3460-3374
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S0901502719301079?via%3Dihub

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