Evaluation of potential biomarkers for the diagnosis and monitoring of Systemic Lupus Erythematosus using the Cytometric Beads Array (CBA)

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dc.creatorLuan c v Alves
dc.creatorIsabela Moreira Gondim
dc.creatorLuanne f Ferreira
dc.creatorTania Mara Guimaraes
dc.creatorVicente de Paula Coelho Peixoto Toledo
dc.creatorMaria Das Graças Carvalho
dc.creatorFernanda Freire Campos
dc.creatorEdna Afonso Reis
dc.creatorGilda Aparecida Ferreira
dc.creatorDebora Cerqueira Calderaro
dc.creatorJoana Starling de Carvalho
dc.creatorPaulo m Padua
dc.creatorWalter Batista Cicarini
dc.date.accessioned2023-07-20T21:30:36Z
dc.date.accessioned2025-09-09T00:21:18Z
dc.date.available2023-07-20T21:30:36Z
dc.date.issued2019-08-30
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1016/j.cca.2019.08.033
dc.identifier.issn00098981
dc.identifier.urihttps://hdl.handle.net/1843/56819
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofClinica Chimica Acta
dc.rightsAcesso Aberto
dc.subjectLúpus Eritematoso Sistêmico
dc.subjectBiomarcadores
dc.subject.otherSystemic Lupus Erythematosus
dc.subject.otherBiomarkers
dc.subject.otherdiagnostico
dc.titleEvaluation of potential biomarkers for the diagnosis and monitoring of Systemic Lupus Erythematosus using the Cytometric Beads Array (CBA)
dc.typeArtigo de periódico
local.citation.epage23
local.citation.issue2019
local.citation.spage16
local.citation.volume499
local.description.resumoBackground: Systemic Lupus Erythematosus (SLE) is an autoimmune, multisystemic disease. Currently diagnosis depends on complex criteria developed by the American College of Rheumatology. Moreover, the lack of specific biomarkers also challenges the diagnosis. Methods: Inflammatory biomarkers such as IL-8, IP-10, MIG, MIP-1α and RANTES were measured in serum samples from SLE patients and subjects in control groups (patients with other autoimmune diseases and healthy individuals). Forty-six SLE patients (22 patients with low activity, SLEDAI-2 K ≤ 4, 24 patients with moderate/ high activity, SLEDAI-2 K > 4), 42 patients with other autoimmune diseases (OAD group), and 8 healthy vo lunteers participated in this study. Results: MIG (p < .001) and RANTES (p < .001) concentrations in SLE patients and healthy controls, and IP-10 concentrations in SLE patients with different disease activities (low activity, p < .01, moderate/high activity, p < .05) differed significantly. IL-8 (p < .001) and MIP-1α (p < .001) concentrations in SLE patients differed from those in patients from the OAD group. IL-8 (p < .05), IP-10 (p < .01), MIG (p < .05), MIP-1α (p < .001), and RANTES (p < .05) were correlated with SLE activity; their concentrations in SLE patients with low and moderate/high activity differed significantly. Conclusions: Given the findings of this study, one can envision the possibility of future use of some of these cytokines to assist in the screening of SLE patients, or even in monitoring disease activity.
local.publisher.countryBrasil
local.publisher.departmentMEDICINA - FACULDADE DE MEDICINA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/abs/pii/S0009898119320285?via%3Dihub

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