Oral tolerance as antigen-specific immunotherapy

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dc.creatorNatália Pinheiro Rosa
dc.creatorLícia Torres
dc.creatorMariana de Almeida Oliveira
dc.creatorMarcos Felipe Andrade-oliveira
dc.creatorMauro Andrade de Freitas Guimarães
dc.creatorMonique Macedo Coelho
dc.creatorJuliana de Lima Alves
dc.creatorTatiani Uceli Maioli
dc.creatorAna M. Caetano Faria
dc.date.accessioned2024-03-20T20:14:11Z
dc.date.accessioned2025-09-09T01:27:39Z
dc.date.available2024-03-20T20:14:11Z
dc.date.issued2021-08-25
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1093/immadv/ltab017
dc.identifier.issn2732-4303
dc.identifier.urihttps://hdl.handle.net/1843/66225
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofImmunotherapy Advances
dc.rightsAcesso Aberto
dc.subjectImunologia
dc.subjectImunoterapia
dc.subjectMucosa bucal
dc.subjectLinfócitos T Reguladores
dc.subject.otherOral tolerance
dc.subject.otherGut mucosa
dc.subject.otherOral immunotherapy
dc.subject.otherRegulatory T Cells
dc.titleOral tolerance as antigen-specific immunotherapy
dc.typeArtigo de periódico
local.citation.epage21
local.citation.issue1
local.citation.spage1
local.citation.volume1
local.description.resumoOral tolerance is a physiological phenomenon described more than a century ago as a suppressive immune response to antigens that gain access to the body by the oral route. It is a robust and long-lasting event with local and systemic effects in which the generation of mucosally induced regulatory T cells (iTreg) plays an essential role. The idea of using oral tolerance to inhibit autoimmune and allergic diseases by oral administration of target antigens was an important development that was successfully tested in 1980s. Since then, several studies have shown that feeding specific antigens can be used to prevent and control chronic inflammatory diseases in both animal models and clinically. Therefore, oral tolerance can be classified as an antigen-specific form of oral immunotherapy (OIT). In the light of novel findings on mechanisms, sites of induction and factors affecting oral tolerance, this review will focus on specific characteristics of oral tolerance induction and how they impact in its therapeutic application.
local.identifier.orcidhttps://orcid.org/0000-0002-2048-0318
local.identifier.orcidhttps://orcid.org/0000-0002-0604-8510
local.identifier.orcidhttps://orcid.org/0000-0002-7538-3208
local.publisher.countryBrasil
local.publisher.departmentENF - DEPARTAMENTO DE NUTRIÇÃO
local.publisher.departmentENFERMAGEM - ESCOLA DE ENFERMAGEM
local.publisher.departmentICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://academic.oup.com/immunotherapyadv/article/1/1/ltab017/6357638

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