Strategies for metabolomic analysis of damaged skin from cell and tissue samples using gas chromatography-mass spectrometry

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dc.creatorSamantha Christina Hermano Rodrigues
dc.creatorHelvécio Costa Menezes
dc.creatorDawidson Assis Gomes
dc.creatorZenilda de Lourdes Cardeal
dc.date.accessioned2026-02-23T17:55:33Z
dc.date.issued2023
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.identifier.doihttps://dx.doi.org/10.21577/0103-5053.20230005
dc.identifier.issn1678-4790
dc.identifier.urihttps://hdl.handle.net/1843/1712
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of the Brazilian Chemical Society
dc.rightsAcesso aberto
dc.subjectBioquímica analítica
dc.subjectPreparação de amostra (Química)
dc.subjectPele
dc.subjectCromatografia de gás
dc.subjectEspectrometria de massa
dc.subject.otherMetabolomics
dc.subject.otherGC-MS
dc.subject.otherHuman skin
dc.subject.otherSample preparation
dc.subject.otherData analysis
dc.titleStrategies for metabolomic analysis of damaged skin from cell and tissue samples using gas chromatography-mass spectrometrypt_BR
dc.typeArtigo de periódico
local.citation.epage484
local.citation.issue4
local.citation.spage471
local.citation.volume34
local.creator.Latteshttp://lattes.cnpq.br/3012706650360568
local.creator.Latteshttp://lattes.cnpq.br/8501096347724709
local.creator.Latteshttp://lattes.cnpq.br/7990397233201223
local.description.resumoMetabolomics can provide a readout of the biochemical and physiological state of a biological system. Gas chromatography coupled to mass spectrometry (GC-MS) has been widely applied for metabolomic analysis due to its numerous advantages, such as good sensitivity, high resolution, reproducibility, extensive database, lower acquisition cost and greater coverage. In addition, combined with efficient methods of sampling and sample preparation, the metabolomic analysis of damaged skin based on GC-MS can provide an important step toward elucidating several skin diseases. Based on this, this review presents a comprehensive overview of sampling, sample preparation, data processing and GC-MS analysis of metabolomic studies of damaged skin. Also, part of the biological interpretation of metabolites such as cis- and trans-urocanic acid (UCA) altered in photoexposed skin and lauric acid (C12:0) and palmitic acid (C16:0) in melanoma is discussed. Finally, to improve decision-making, a part of the integration of skin metabolomics with other omics sciences for the advancement of diagnosis is presented.
local.identifier.orcidhttps://orcid.org/0000-0002-5759-612X
local.identifier.orcidhttps://orcid.org/0000-0001-7714-991X
local.identifier.orcidhttps://orcid.org/0000-0003-1383-6299
local.publisher.countryBrasil
local.publisher.departmentICX - DEPARTAMENTO DE QUÍMICA
local.publisher.departmentICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIA
local.publisher.initialsUFMG
local.subject.cnpqCIENCIAS EXATAS E DA TERRA::QUIMICA
local.url.externawww.scielo.br/j/jbchs/a/S6QbjNpRH6LhkxYvHTgTNZs/

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