Megavoltage radiotherapy effects on organs of the reticuloendothelial system
| dc.creator | Fernando Pereira | |
| dc.creator | Andy Petroianu | |
| dc.creator | Jony Marques Geraldo | |
| dc.creator | Claubia Pereira | |
| dc.date.accessioned | 2025-05-16T20:22:28Z | |
| dc.date.accessioned | 2025-09-08T23:33:31Z | |
| dc.date.available | 2025-05-16T20:22:28Z | |
| dc.date.issued | 2023 | |
| dc.format.mimetype | ||
| dc.identifier.doi | https://doi.org/10.1590/acb384123 | |
| dc.identifier.issn | 1678-2674 | |
| dc.identifier.uri | https://hdl.handle.net/1843/82336 | |
| dc.language | eng | |
| dc.publisher | Universidade Federal de Minas Gerais | |
| dc.relation.ispartof | Acta cirúrgica brasileira | |
| dc.rights | Acesso Aberto | |
| dc.subject | Mononuclear Phagocyte System | |
| dc.subject | Kupffer Cells | |
| dc.subject | Radiotherapy | |
| dc.subject.other | Mononuclear Phagocyte System | |
| dc.subject.other | Kupffer Cells | |
| dc.subject.other | Radiotherapy | |
| dc.title | Megavoltage radiotherapy effects on organs of the reticuloendothelial system | |
| dc.type | Artigo de periódico | |
| local.citation.epage | 7 | |
| local.citation.issue | e384123 | |
| local.citation.spage | 1 | |
| local.citation.volume | 38 | |
| local.description.resumo | Purpose: To study the uptake capacity of cells from the reticuloendothelial system after irradiation with high-energy X-rays. Methods: Eighteen male Wistar rats were distributed in three groups: group A (n = 6): control, unirradiated animals studied alongside animals from group B; group B (n = 6) and group C (n = 6): animals irradiated and studied after 24 and 48 hours, respectively. The rats were anesthetized and placed on a 10 MV linear accelerator. Next, they were irradiated in the abdominal region, with 8 Gy. Twenty-four (groups A and B) and 48 hours later (group C), a colloidal carbon solution (1 mL/kg) was intravenously injected in the tail vein. Fifty minutes later, the spleens and livers were withdrawn and prepared to be studied. Kupffer cells and splenic macrophages containing carbon pigments were counted in an optical microscope. Arithmetic means were calculated for each group and compared among them. Results: X-rays were associated with a reduced number of Kupffer cells containing colloidal carbon, proliferation and enlargement of biliary ducts, hypoplasia, and hepatocyte necrosis. In the irradiated spleen, the colloidal carbon uptake was concentrated in the marginal zone around the white pulp, with an inexpressive uptake of pigments by macrophages from white and red pulps. Conclusion: The X-rays in the rat abdomen are associated with a reduction in the Kupffer cells uptake of colloidal carbon, hepatocyte disorders, bile duct proliferation, and splenic uptake of colloidal carbon concentrated in the marginal zone. | |
| local.publisher.country | Brasil | |
| local.publisher.department | ENG - DEPARTAMENTO DE ENGENHARIA NUCLEAR | |
| local.publisher.department | MED - DEPARTAMENTO DE CIRURGIA | |
| local.publisher.initials | UFMG | |
| local.url.externa | https://www.scielo.br/j/acb/a/GLJQQC7zB34jm7rDpfr8ZfB/?format=pdf&lang=en |