Kinetics of inflammatory and pain biomarkers during self-management program treatment of Temporomandibular Disorders - Myofascial Pain Syndrome: a prospective observational study
| dc.creator | Flávia Fonseca Carvalho Soares | |
| dc.creator | Carolina Cavaliéri Gomes | |
| dc.creator | Elizete Maria Pereira | |
| dc.creator | Elisa Carvalho de Siqueira | |
| dc.creator | Fabricio Tinôco Alvim de Souza | |
| dc.creator | Letícia Martins Guimarães | |
| dc.creator | Renan Pedra de Souza | |
| dc.creator | José Mário Neto Soares | |
| dc.creator | Marcus Vinícius Gomez | |
| dc.creator | Ricardo Santiago Gomez | |
| dc.date.accessioned | 2024-07-19T21:48:35Z | |
| dc.date.accessioned | 2025-09-09T00:52:30Z | |
| dc.date.available | 2024-07-19T21:48:35Z | |
| dc.date.issued | 2021 | |
| dc.description.abstract | Objetivos: Investigar a taxa de fluxo salivar juntamente com os níveis salivares de IL-6, IL-1β, substância P, glutamato e oxigênio reativo espécies (ROS) em pacientes com disfunção temporomandibular (dor miofascial) antes e durante o programa de autogestão. Além disso, avaliar a associação da intensidade da dor com a concentração de biomarcadores. Materiais e método: A saliva de dezenove pacientes com diagnóstico de DTM-DTM foi coletada antes do programa de automanejo e durante o tratamento (4 e 8 semanas). Resultados: Não houve alteração significativa nos níveis de expressão dos biomarcadores avaliados e a taxa de fluxo salivar ao longo do tempo foi encontrado. Não foi encontrada correlação entre a intensidade da dor e os parâmetros moleculares avaliados em nenhum dos três momentos. Conclusão: os biomarcadores avaliados e as taxas de fluxo salivar não se alteraram durante oito semanas de programa de automanejo intervenção na amostra avaliada. | |
| dc.description.sponsorship | CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico | |
| dc.format.mimetype | ||
| dc.identifier.doi | 10.51626/ijoh.2021.01.00003 | |
| dc.identifier.issn | 2770-0631 | |
| dc.identifier.uri | https://hdl.handle.net/1843/71126 | |
| dc.language | eng | |
| dc.publisher | Universidade Federal de Minas Gerais | |
| dc.relation.ispartof | International Journal on Oral Health | |
| dc.rights | Acesso Aberto | |
| dc.subject | Biomarcadores | |
| dc.subject | Síndromes da dor miofascial | |
| dc.subject | Transtornos da articulação temporomandibular | |
| dc.subject | Saliva | |
| dc.subject.other | Pain biomarkers | |
| dc.subject.other | Myofascial pain | |
| dc.subject.other | Temporomandibular disorders | |
| dc.subject.other | Salivary flow | |
| dc.subject.other | Self-management program treatment | |
| dc.title | Kinetics of inflammatory and pain biomarkers during self-management program treatment of Temporomandibular Disorders - Myofascial Pain Syndrome: a prospective observational study | |
| dc.type | Artigo de periódico | |
| local.citation.epage | 14 | |
| local.citation.spage | 9 | |
| local.citation.volume | 1 | |
| local.description.resumo | Objectives: Investigate the salivary flow rate together with salivary levels of IL-6, IL-1β, substance P, glutamate and reactive oxygen species (ROS) in patients with temporomandibular disorders (myofascial pain) before and during self-management program. Moreover, evaluate the association of pain intensity with the biomarkers concentration. Materials and method: Saliva of nineteen patients diagnosed with TMD-MD was collected before self-management program and during the treatment (4 and 8 weeks). Results: No significant alteration of the expression levels of the biomarkers evaluated and the salivary flow rate throughout time was found. No correlation was found between pain intensity and the molecular parameters evaluated at any of the three moments. Conclusion: the biomarkers evaluated and salivary flow rates did not change during eight weeks of self-management program intervention in the sample evaluated | |
| local.identifier.orcid | https://orcid.org/0000-0002-4970-3626 | |
| local.identifier.orcid | https://orcid.org/0000-0002-0732-7183 | |
| local.identifier.orcid | https://orcid.org/0000-0002-1022-0336 | |
| local.identifier.orcid | https://orcid.org/0000-0002-9479-4432 | |
| local.identifier.orcid | https://orcid.org/0000-0002-6082-930X | |
| local.identifier.orcid | https://orcid.org/0000-0001-8770-8009 | |
| local.publisher.country | Brasil | |
| local.publisher.department | ICB - DEPARTAMENTO DE MORFOLOGIA | |
| local.publisher.department | ICB - DEPARTAMENTO DE PATOLOGIA | |
| local.publisher.initials | UFMG | |
| local.url.externa | https://skeenapublishers.com/journal/ijoh/IJOH-01-00003.pdf |
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