Vasoactive intestinal peptide degradation might influence interleukin-17 expression in cardiac chagasic patients

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dc.creatorFrancielle Beltrãopereira
dc.creatorWalderez Ornelas Dutra
dc.creatorKenneth j. Gollob
dc.creatorEdna Afonso Reis
dc.creatorAna Laura Grossi de Oliveira
dc.creatorManoel Otávio da Costa Rocha
dc.creatorCristiane Alves da Silva Menezes
dc.date.accessioned2024-01-10T19:43:19Z
dc.date.accessioned2025-09-08T23:58:51Z
dc.date.available2024-01-10T19:43:19Z
dc.date.issued2018
dc.format.mimetypepdf
dc.identifier.doi10.1590/s1678-9946201860057
dc.identifier.issn16789946
dc.identifier.urihttps://hdl.handle.net/1843/62545
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofRevista do Instituto de Medicina Tropical de São Paulo
dc.rightsAcesso Aberto
dc.subjectChagas disease
dc.subjectTryptases
dc.subjectChymases
dc.subjectVasoactive Intestinal Peptide
dc.subjectInterleukin-17
dc.subject.otherChagas disease
dc.subject.otherTryptases
dc.subject.otherChymases
dc.subject.otherVasoactive Intestinal Peptide
dc.subject.otherInterleukin-17
dc.titleVasoactive intestinal peptide degradation might influence interleukin-17 expression in cardiac chagasic patients
dc.typeArtigo de periódico
local.citation.epage10
local.citation.issuee57
local.citation.spage1
local.citation.volume60
local.description.resumoThe vasoactive intestinal peptide (VIP) expression is lower in cardiac chagasic patients and is related to worse cardiac function. The reduction of VIP in patients with Chagas disease may be a result of its enhanced degradation. To test this hypothesis, the tryptase and chymase expression was evaluated. We also related VIP levels with interleukin-17 (IL 17) expression since VIP may modulate IL-17 production. Plasma levels of chymase were higher in chagasic patients. Conversely, VIP/chymase and VIP/tryptase ratios were lower in chagasic patients when compared to non-infected individuals. Besides, the VIP/chymase ratio was lower in chagasic cardiac patients in comparison with the indeterminate group. A positive correlation between tryptase and chymase levels was observed in chagasic cardiac patients. In relation to IL-17, we observed a higher expression of this cytokine in the cardiac form of the disease than in the indeterminate form. IL-17/VIP ratio was higher in the cardiac form in comparison with non-infected or indeterminate form. These results suggest that the low levels of VIP observed in chagasic patients could be due to an increased production of chymase and/or to the additive effect of the interaction between chymase and tryptase in the cardiac form. Moreover, the decreased VIP expression may contribute to the increase of IL-17 in chagasic cardiac patients.
local.publisher.countryBrasil
local.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS
local.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIA
local.publisher.departmentICX - DEPARTAMENTO DE ESTATÍSTICA
local.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICA
local.publisher.initialsUFMG
local.url.externahttps://www.scielo.br/j/rimtsp/a/TgN6rnJcFxkx6gFndWbK6nB/?lang=en

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