Localization of angiotensin-(1-7) and Mas receptor in the rat ovary throughout the estrous cycle

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dc.creatorVirgínia Mara Pereira
dc.creatorFernando Marcos dos Reis
dc.creatorGeovanni Dantas Cassali
dc.creatorSergio Henrique Sousa Santos
dc.creatorMaíra Casalechi Badin Telles
dc.creatorRobson Augusto Souza dos Santos
dc.creatorAdelina Martha dos Reis
dc.date.accessioned2022-12-09T13:34:38Z
dc.date.accessioned2025-09-09T00:45:38Z
dc.date.available2022-12-09T13:34:38Z
dc.date.issued2020-09-01
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.identifier.doi10.1007/s10735-020-09910-8
dc.identifier.issn1567-2387
dc.identifier.urihttps://hdl.handle.net/1843/47854
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Molecular Histology
dc.rightsAcesso Restrito
dc.subjectAngiotensina
dc.subjectSistema renina-angiotensina
dc.subjectOvários
dc.subject.otherAngiotensin-(1-7)
dc.subject.otherAngiotensin II
dc.subject.otherACE 2
dc.subject.otherovary
dc.subject.otherMas receptor
dc.titleLocalization of angiotensin-(1-7) and Mas receptor in the rat ovary throughout the estrous cycle
dc.typeArtigo de periódico
local.citation.epage647
local.citation.spage639
local.citation.volume51
local.description.resumoWe have previously demonstrated the presence of Angiotensin (Ang)-(1-7) in rat ovary homogenates and its stimulatory effect on estradiol and progesterone production. The present study was undertaken to identify the cellular localization of Ang-(1-7) and its receptor Mas in the rat ovary in the different phases of the estrous cycle. Ang-(1-7) and Mas were localized by immunohistochemistry and Mas mRNA expression was assessed by RT-PCR. Immunostaining for both Ang-(1-7) and Mas was found in all phases of the estrous cycle, particularly in the thecal and interstitial cells, as well as in regressing corpora lutea. However, granulosa cells were positive only in antral and preovulatory follicles at proestrus and estrus phases. This pattern contrasted with the distribution of the octapeptide Ang II, which was abundant in granulosa but not in theca cells. In addition, the expression of Mas mRNA was demonstrated in all estrous cycle phases. Angiotensin-converting enzyme activity did not vary between estrous cycle phases, whereas prolyl endopeptidase activity was significantly higher in diestrus and neutral endopeptidase activity was significantly higher in metestrus. These data provide the first evidence that new RAS components are dynamically expressed in the ovary across the rat estrous cycle. Further functional studies should clarify the role of Ang-(1-7) signaling through Mas receptor in the regulation of ovarian physiology.
local.publisher.countryBrasil
local.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS
local.publisher.initialsUFMG
local.url.externahttps://link.springer.com/article/10.1007/s10735-020-09910-8

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