Immunohistochemical study of fibronectin, tenascin and type i collagen in tongue and lip carcinomas

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dc.creatorJoão Luiz de Miranda
dc.creatorFelipe Rodrigues de Matos
dc.creatorFrederico Santos Lages
dc.creatorDhelfeson Willya Douglas de Oliveira
dc.creatorRoseana de Almeida Freitas
dc.date.accessioned2022-10-04T19:05:40Z
dc.date.accessioned2025-09-09T01:03:56Z
dc.date.available2022-10-04T19:05:40Z
dc.date.issued2017-12-15
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.20396/bjos.v16i0.8651061
dc.identifier.issn16773225
dc.identifier.urihttps://hdl.handle.net/1843/45944
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofBrazilian Journal of Oral Sciences
dc.rightsAcesso Aberto
dc.subjectImmunohistochemistry
dc.subjectMouth neoplasms
dc.subjectFibronectins
dc.subjectCollagen
dc.subject.otherImmunohistochemistry
dc.subject.otherOral cancer
dc.subject.otherTenascin
dc.subject.otherFibronectin
dc.subject.otherCollagen
dc.titleImmunohistochemical study of fibronectin, tenascin and type i collagen in tongue and lip carcinomas
dc.typeArtigo de periódico
local.citation.epage13
local.citation.issue1
local.citation.spage01
local.citation.volume16
local.description.resumoAIM: The aim was to compare the immunoexpression of extracellular matrix proteins in squamous cell carcinomas of tongue (SCCTo) and lower lip (SCCLi). METHODS: Eleven SCCTo and 11 SCCLi were selected and examined according to Bryne’s method (1998). For immunohistochemical study utilized antibodies to fibronectin, tenascin and type I collagen. Histopathologic and immunohistochemical analysis were performed on the tumor invasive front. RESULTS: All SCCTo were classified in high score malignant grade and all SCCLi in lower score. Fibronectin showed strong immunorreactivity in the peritumoral basement membrane (BM) in 91% of SCCTo and all cases of SCCLi, while in the tumor stroma (TS) all cases of SCCTo and SCCLi had strong intensity. Tenascin had strong expression in BM of 91% cases of SCCTo and 63.4% of SCCLi and in TS had strong expression in 91% cases of SCCTo and 54.6% of SCCLi. Type I collagen demonstrated weak immunoreactivity in the TS of 72.7% cases of SCCTo and 63.4% of SCCLi. CONCLUSION: These results may suggest that the strong expression of fibronectin and tenascin proteins and the weak expression of type I collagen could play a role in the invasive process of oral SCC.
local.publisher.countryBrasil
local.publisher.departmentFAO - FACULDADE DE ODONTOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/8651061

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