Treatment for chemical burning using liquid crystalline nanoparticles as an ophthalmic delivery system for pirfenidone

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dc.creatorRummenigge Oliveira Silva
dc.creatorArmando da Silva Cunha Júnior
dc.creatorBruna Lopes da Costa
dc.creatorFlávia Rodrigues da Silva
dc.creatorCarolina Nunes da Silva
dc.creatorMayara Rodrigues Brandão de Paiva
dc.creatorLays Fernanda Nunes Dourado
dc.creatorÂngelo Malachias de Souza
dc.creatorAdriano Antunes de Souza Araújo
dc.creatorPaula Santos Nunes
dc.date.accessioned2023-04-10T20:02:46Z
dc.date.accessioned2025-09-09T01:28:05Z
dc.date.available2023-04-10T20:02:46Z
dc.date.issued2019
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.description.sponsorshipINCT – Instituto nacional de ciência e tecnologia (Antigo Instituto do Milênio)
dc.description.sponsorshipFAPESP - Fundação de Amparo à Pesquisa do Estado de São Paulo
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1016/j.ijpharm.2019.118466
dc.identifier.issn1873-3476
dc.identifier.urihttps://hdl.handle.net/1843/51758
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofInternational Journal of Pharmaceutics
dc.rightsAcesso Aberto
dc.subjectQueimaduras químicas
dc.subjectNanopartículas
dc.subjectCórnea
dc.subjectCicatrização de feridas
dc.subject.otherOcular chemical burns
dc.subject.otherPirfenidone
dc.subject.otherLiquid crystalline nanoparticles
dc.subject.otherCornea
dc.subject.otherWound healing
dc.titleTreatment for chemical burning using liquid crystalline nanoparticles as an ophthalmic delivery system for pirfenidone
dc.typeArtigo de periódico
local.citation.epage14
local.citation.spage1
local.citation.volume568
local.description.resumoSome recent studies have shown that pirfenidone (PFD) has favorable results in the healing process of the cornea. However, PFD in solution exhibits short half-life after topical application, and in this context, a liquid crystal nanoparticle system containing PFD (PFD-LCNPs) was developed. The nanoparticles were characterized by transmission electron microscopy, atomic force microscopy, small angle X-ray diffraction and polarized light microscopy. The PFD-LCNPs had particle size and zeta potential of 247.3 nm and −33.60 mV (stores at 4 °C), respectively, and 257.5 nm and −46.00 mV (stored at 25 °C), respectively. The pH of the formulation was 6.9 and the encapsulation efficiency was 35.9%. The in vitro release profiles indicated that PFD sustained release from PFD-LCNPs for up to 12 h. In vitro study of ocular irritation (HET-CAM test) concluded that components of the formulation are well tolerated for ocular administration. Corneal re-epithelialization time after chemical burning was significantly reduced in rabbits treated with PFD-loaded LCNPs when compared to the group treated with a vehicle. In addition, the anti-inflammatory action of pirfenidone was observed by reducing myeloperoxidase activity (MPO) and inflammatory cells in the histology of the tissues of animals treated with PFD-LCNPs. These findings indicated that the PFD-LCNPs might have the potential for effective ocular drug delivery.
local.identifier.orcidhttps://orcid.org/0000-0002-4506-7570
local.identifier.orcidhttps://orcid.org/0000-0002-1161-8936
local.identifier.orcidhttps://orcid.org/0000-0003-3007-9795
local.identifier.orcidhttps://orcid.org/0000-0003-1382-2487
local.identifier.orcidhttps://orcid.org/0000-0002-6449-7904
local.identifier.orcidhttps://orcid.org/0000-0001-5287-455X
local.identifier.orcidhttps://orcid.org/0000-0002-8703-4283
local.identifier.orcidhttps://orcid.org/0000-0003-3588-0178
local.publisher.countryBrasil
local.publisher.departmentFAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOS
local.publisher.departmentICX - DEPARTAMENTO DE FÍSICA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S037851731930506X

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