An exploratory study of the metabolite profiling from pesticides exposed workers

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dc.creatorDaniela Magalhães Nolasco
dc.creatorMichele Polyana Rocha Mendes
dc.creatorLuiz Paulo de Aguiar Marciano
dc.creatorLuiz Filipe Costa
dc.creatorAdriana Nori de Macedo
dc.creatorIsarita Martins Sakakibara
dc.creatorAlessandra Cristina Pupin Silvério
dc.creatorMaria José Nunes Paiva
dc.creatorLeiliane Coelho André
dc.date.accessioned2025-03-06T20:13:33Z
dc.date.accessioned2025-09-08T23:30:40Z
dc.date.available2025-03-06T20:13:33Z
dc.date.issued2023-04-27
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.3390/metabo13050596
dc.identifier.issn2218-1989
dc.identifier.urihttps://hdl.handle.net/1843/80542
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofMetabolites
dc.rightsAcesso Aberto
dc.subjectPesticidas
dc.subjectPesticida Toxicologia
dc.subjectPlasma
dc.subject.otherPesticides
dc.subject.otherUntarget metabolomic
dc.subject.otherOccupational toxicology
dc.subject.otherUPLC-Q-TOF-MS
dc.subject.otherPlasma
dc.subject.otherUrine
dc.titleAn exploratory study of the metabolite profiling from pesticides exposed workers
dc.typeArtigo de periódico
local.citation.epage25
local.citation.issue5
local.citation.spage1
local.citation.volume13
local.description.resumoPesticides constitute a category of chemical products intended specifically for the control and mitigation of pests. With their constant increase in use, the risk to human health and the environment has increased proportionally due to occupational and environmental exposure to these compounds. The use of these chemicals is associated with several toxic effects related to acute and chronic toxicity, such as infertility, hormonal disorders and cancer. The present work aimed to study the metabolic profile of individuals occupationally exposed to pesticides, using a metabolomics tool to identify potential new biomarkers. Metabolomics analysis was carried out on plasma and urine samples from individuals exposed and non-exposed occupationally, using liquid chromatography coupled with mass spectrometry (UPLC-MS). Non-targeted metabolomics analysis, using principal component analysis (PCA), partial least squares discriminant analysis (PLS-DA) or partial least squares discriminant orthogonal analysis (OPLS-DA), demonstrated good separation of the samples and identified 21 discriminating metabolites in plasma and 17 in urine. The analysis of the ROC curve indicated the compounds with the greatest potential for biomarkers. Comprehensive analysis of the metabolic pathways influenced by exposure to pesticides revealed alterations, mainly in lipid and amino acid metabolism. This study indicates that the use of metabolomics provides important information about complex biological responses.
local.identifier.orcidhttps://orcid.org/0000-0002-0916-1068
local.identifier.orcidhttps://orcid.org/0000-0001-9721-7406
local.identifier.orcidhttps://orcid.org/0000-0002-5036-9717
local.identifier.orcidhttps://orcid.org/0000-0002-4125-3755
local.identifier.orcidhttps://orcid.org/0000-0001-7471-3773
local.identifier.orcidhttps://orcid.org/0000-0003-2093-2713
local.identifier.orcidhttps://orcid.org/0000-0003-0840-0810
local.publisher.countryBrasil
local.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS
local.publisher.initialsUFMG
local.url.externahttps://www.mdpi.com/2218-1989/13/5/596

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