Tailed giant Tupanvirus possesses the most complete translational apparatus of the known virosphere

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dc.creatorJônatas Abrahão
dc.creatorLorena Silva
dc.creatorLudmila Santos Silva
dc.creatorJacques Yaacoub Bou Khalil
dc.creatorRodrigo Rodrigues
dc.creatorThalita Arantes
dc.creatorFelipe Assis
dc.creatorPaulo Boratto
dc.creatorMiguel Andrade
dc.creatorErna Geessien Kroon
dc.creatorBergmann Ribeiro
dc.creatorIvan Bergier
dc.creatorHerve Seligmann
dc.creatorEric Ghigo
dc.creatorPhilippe Colson
dc.creatorAnthony Levasseur
dc.creatorGuido Kroemer
dc.creatorDidier Raoult
dc.creatorBernard La Scola
dc.date.accessioned2025-02-07T21:28:27Z
dc.date.accessioned2025-09-09T00:30:52Z
dc.date.available2025-02-07T21:28:27Z
dc.date.issued2018-02-27
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1038/s41467-018-03168-1
dc.identifier.issn2041-1723
dc.identifier.urihttps://hdl.handle.net/1843/79771
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofNature Communications
dc.rightsAcesso Aberto
dc.subjectMimiviridae
dc.subjectAmeba
dc.subjectVírus
dc.titleTailed giant Tupanvirus possesses the most complete translational apparatus of the known virosphere
dc.typeArtigo de periódico
local.citation.epage12
local.citation.spage1
local.citation.volume9
local.description.resumoHere we report the discovery of two Tupanvirus strains, the longest tailed Mimiviridae members isolated in amoebae. Their genomes are 1.44–1.51 Mb linear double-strand DNA coding for 1276–1425 predicted proteins. Tupanviruses share the same ancestors with mimivirus lineages and these giant viruses present the largest translational apparatus within the known virosphere, with up to 70 tRNA, 20 aaRS, 11 factors for all translation steps, and factors related to tRNA/mRNA maturation and ribosome protein modification. Moreover, two sequences with significant similarity to intronic regions of 18 S rRNA genes are encoded by the tupanviruses and highly expressed. In this translation-associated gene set, only the ribosome is lacking. At high multiplicity of infections, tupanvirus is also cytotoxic and causes a severe shutdown of ribosomal RNA and a progressive degradation of the nucleus in host and non-host cells. The analysis of tupanviruses constitutes a new step toward understanding the evolution of giant viruses.
local.identifier.orcidhttps://orcid.org/0000-0001-9420-1791
local.identifier.orcidhttps://orcid.org/0000-0002-4272-5208
local.identifier.orcidhttps://orcid.org/0000-0001-7531-888X
local.identifier.orcidhttps://orcid.org/0000-0003-2721-3826
local.identifier.orcidhttps://orcid.org/0000-0002-1061-196X
local.identifier.orcidhttps://orcid.org/0000-0002-1076-8617
local.identifier.orcidhttps://orcid.org/0000-0002-0445-6940
local.identifier.orcidhttps://orcid.org/0000-0001-5760-7178
local.identifier.orcidhttps://orcid.org/0000-0001-6285-0308
local.identifier.orcidhttps://orcid.org/0000-0003-2989-7539
local.identifier.orcidhttps://orcid.org/0000-0002-9334-4405
local.identifier.orcidhttps://orcid.org/0000-0002-0633-5974
local.identifier.orcidhttps://orcid.org/0000-0001-8006-7704
local.publisher.countryBrasil
local.publisher.departmentICB - DEPARTAMENTO DE MICROBIOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://www.nature.com/articles/s41467-018-03168-1#rightslink

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