Probiotic consumption decreases the number of osteoclasts during orthodontic movement in mice

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dc.creatorCamila Alessandra Pazzini
dc.creatorLuciano José Pereira
dc.creatorTarcília Aparecida da Silva
dc.creatorCarina Cristina Montalvany-Antonucci
dc.creatorSoraia Macari
dc.creatorLeandro Silva Marques
dc.creatorSaul Martins de Paiva
dc.date.accessioned2023-03-20T19:35:16Z
dc.date.accessioned2025-09-09T00:40:44Z
dc.date.available2023-03-20T19:35:16Z
dc.date.issued2017-07
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1016/j.archoralbio.2017.02.017
dc.identifier.issn00039969
dc.identifier.urihttps://hdl.handle.net/1843/51062
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofArchives of Oral Biology
dc.rightsAcesso Restrito
dc.subjectTooth movement techniques
dc.subjectProbiotics
dc.subjectOsteoclasts
dc.subjectOrthodontics
dc.subjectOsteoblasts
dc.subject.otherConsumo de probióticos
dc.subject.otherOsteoclastos
dc.subject.otherMovimento ortodôntico
dc.subject.otherMicrobiologia oral
dc.subject.otherFarmacologia
dc.subject.otherPatologia Bucal
dc.titleProbiotic consumption decreases the number of osteoclasts during orthodontic movement in mice
dc.typeArtigo de periódico
local.citation.epage34
local.citation.spage30
local.citation.volume79
local.description.resumoAims: The aim of the present study was to investigate the effect of probiotic (Bacillus Subtilis) supplementation on bone remodelling induced by mechanical loading. Methods: C57BL/6 mice were divided in two groups: (1) Probiotic and (2) Vehicle (water). The probiotic (1.5×108CFU/mL) was administered orally for 14 days, starting two days before the induction of orthodontic tooth movement (OTM). OTM was determined by histomorphometric analysis by comparing the right to the left side of the maxilla. The number of osteoclasts was determined by counting TRAP-positive cells. Osteoblasts were counted on Masson's trichrome-stained slides. Results: OTM was similar between groups (with and without probiotic supplementation) (p=0.46). The number of TRAP-positive cells increased (p<0.01) on the experimental side (where the spring coil was installed) in comparison to the control side in both groups. However, the number of osteoclasts decreased (p˂0.01) in the probiotic group, in comparison to the vehicle group. There was an increase in the number of osteoblasts (p˂0.05) in both the Vehicle and Probiotic groups on the side under OTM, independent of probiotic supplementation.Conclusion: Oral Supplementation with a probiotic influenced the number of osteoclasts adjacent to the tooth root during orthodontic movement in mice.
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORA
local.publisher.departmentFAO - DEPARTAMENTO DE ODONTOPEDIATRIA E ORTODONTIA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S0003996917300559?via%3Dihub

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