DNA methylation profiles of 22 apoptosis-related genes in odontogenic keratocysts before and after marsupialization

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dc.creatorKaruza Maria Alves Pereira
dc.creatorSara Ferreira dos Santos Costa
dc.creatorNubia Braga Pereira
dc.creatorMarina Gonçalves Diniz
dc.creatorCarolina Cavalieri Gomes
dc.creatorRicardo Santiago Gomez
dc.date.accessioned2025-06-25T19:45:35Z
dc.date.accessioned2025-09-09T01:18:34Z
dc.date.available2025-06-25T19:45:35Z
dc.date.issued2017-11
dc.identifier.doihttps://doi.org/10.1016/j.oooo.2017.07.010
dc.identifier.issn2212-4411
dc.identifier.urihttps://hdl.handle.net/1843/83136
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofOral Surgery Oral Medicine Oral Pathology Oral Radiology
dc.rightsAcesso Restrito
dc.subjectMethylation
dc.subjectOdontogenic cysts
dc.subjectGenes
dc.subjectApoptosis
dc.subjectDNA methylation
dc.subjectGene expression
dc.subjectTherapeutics
dc.titleDNA methylation profiles of 22 apoptosis-related genes in odontogenic keratocysts before and after marsupialization
dc.typeArtigo de periódico
local.citation.epage489
local.citation.issue5
local.citation.spage483
local.citation.volume124
local.description.resumoObjective: Odontogenic keratocysts (OKCs) are cystic lesions of the jaw and tend to recur after treatment. Marsupialization is an effective preliminary treatment for large OKCs. This procedure induces epithelial lining changes in association with reduction of Bcl-2 protein expression, but the underlying mechanisms remain unknown. The purpose of our study was to compare the methylation profile of the apoptosis-related genes of OKCs before and after marsupialization. Study design: We assessed the methylation percentages of the promoter region of 22 apoptosis-related genes in 13 OKCs, both marsupialized and nonmarsupialized lesions, by using methylation quantitative polymerase chain reaction array. We validated the expression of genes that showed the greatest differences in methylation percentages between the 2 groups. Results: LTBR and BCLAF1 showed higher DNA methylation percentages in the marsupialized OKCs, but this difference did not affect gene expression (P > .05). The other 20 genes showed similar DNA methylation in both OKC groups. Conclusions: OKCs show a distinct methylation profile after marsupialization, but this is not followed by gene expression alterations.
local.identifier.orcidhttps://orcid.org/0000-0002-2880-6466
local.identifier.orcidhttps://orcid.org/0000-0001-5150-9227
local.identifier.orcidhttps://orcid.org/0000-0002-6714-3124
local.identifier.orcidhttps://orcid.org/0000-0002-4212-1172
local.identifier.orcidhttps://orcid.org/0000-0003-1580-4995
local.identifier.orcidhttps://orcid.org/0000-0001-8770-8009
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIA
local.publisher.departmentICB - DEPARTAMENTO DE PATOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S2212440317310131?via%3Dihub

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