Eccentric overload muscle damage is attenuated by a novel Angiotensin- (1-7) treatment

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dc.creatorLenice Kappes Becker
dc.creatorNádia Totou
dc.creatorSamara Moura
dc.creatorLucas Miranda Kangussu
dc.creatorRubén Dario Sinisterra Millán
dc.creatorMaria Jose Campagnole dos Santo
dc.creatorDaniel Coelho
dc.creatorDaisy Motta Santos
dc.creatorRobson Augusto Souza dos Santos
dc.date.accessioned2024-01-29T19:47:51Z
dc.date.accessioned2025-09-09T00:18:11Z
dc.date.available2024-01-29T19:47:51Z
dc.date.issued2018
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipINCT – Instituto nacional de ciência e tecnologia (Antigo Instituto do Milênio)
dc.identifier.doihttps://doi.org/10.1055/a-0633-8892
dc.identifier.issn0172-4622
dc.identifier.urihttps://hdl.handle.net/1843/63469
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofInternational Journal of Sports Medicine
dc.rightsAcesso Restrito
dc.subjectMedicina esportiva
dc.subjectQuímica farmacêutica
dc.subjectAngiotensina
dc.subjectMúsculos - Ferimentos e lesões
dc.subject.otherPhysical performance
dc.subject.otherAngiotensin-(1-7)
dc.subject.otherMuscular damage
dc.titleEccentric overload muscle damage is attenuated by a novel Angiotensin- (1-7) treatment
dc.typeArtigo de periódico
local.citation.epage748
local.citation.issue10
local.citation.spage743
local.citation.volume39
local.description.resumoThe development of new strategies to attenuate exercise-induced muscle damage may be helpful for training regimens. The aim of this study was to determine whether a oral formulation of angiotensin Ang-(1-7)[HPβCD/Ang-(1-7)] is effective to reduce pain, and muscle damage markers after eccentric-overload exercise. HPβCD (Placebo) and HPβCD/Ang-(1-7) (Ang-(1-7) group were treated for 7 days (one capsule/day). The pain was measured by visual analogue scale, maximal strength (MS) using force platform. Blood samples were collected for cytokines and creatine kinase (CK) analysis. The Ang-(1-7)-treated group reported less pain immediately (3.46±0.64 vs. placebo 3.80±0.77 cm) and 24 h after exercise (3.07±0.71 vs. 3.73±0.58 cm placebo) and higher MS at 24 h (24±12 N) and 48 h (30±15 N) vs. placebo (-8±9 N and -10±9 N). The CK for Ang-(1-7) (0.5±0.1 and 0.9±0.2 U/L) were lower at 48 and 72 h vs. placebo (fold changes of 1.7±0.5 and 1.5±0.3 U/L). The TNF-α level was lower in the treated group post-exercise (38±2.5 pg/ml) vs. placebo (45±2.9 pg/ml) but no significant changes were observed for IL-6 and IL-10. Our data indicate that treatment with Ang-(1-7) may attenuate pain, some of the muscle damage markers and improves performance following eccentric exercise.
local.identifier.orcidhttps://orcid.org/0000-0002-9462-5719
local.identifier.orcidhttps://orcid.org/0000-0003-0215-0662
local.identifier.orcidhttps://orcid.org/0000-0003-3678-118X
local.identifier.orcidhttps://orcid.org/0000-0001-7656-1849
local.identifier.orcidhttps://orcid.org/0000-0001-9483-4206
local.identifier.orcidhttps://orcid.org/0000-0002-3265-7838
local.publisher.countryBrasil
local.publisher.departmentEEF - DEPARTAMENTO DE ESPORTES
local.publisher.departmentICB - DEPARTAMENTO DE FISIOLOGIA E BIOFÍSICA
local.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIA
local.publisher.departmentICX - DEPARTAMENTO DE QUÍMICA
local.publisher.initialsUFMG
local.url.externahttps://www.thieme-connect.de/products/ejournals/abstract/10.1055/a-0633-8892

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