COMT Val158Met Polymorphism Is Associated with Verbal Working Memory in Neurofibromatosis Type 1

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dc.creatorDanielle de Souza Costa
dc.creatorJonas j. de Paula
dc.creatorAntônio Marcos Alvim Soares Júnior
dc.creatorPatrícia a. Pereira
dc.creatorLeandro f. Malloy-diniz
dc.creatorLuiz o. c. Rodrigues
dc.creatorMarco a. Romano-silva
dc.creatorDébora m. de Miranda
dc.date.accessioned2023-07-27T20:44:47Z
dc.date.accessioned2025-09-08T23:05:18Z
dc.date.available2023-07-27T20:44:47Z
dc.date.issued2016-07-05
dc.format.mimetypepdf
dc.identifier.doi10.3389/fnhum.2016.00334
dc.identifier.issn16625161
dc.identifier.urihttps://hdl.handle.net/1843/57100
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofFrontiers in Human Neuroscience
dc.rightsAcesso Aberto
dc.subjectNeurofibromatose 1
dc.subjectMemória de Curto Prazo
dc.subjectCálculos da Dosagem de Medicamento
dc.subjectNeuropsicologia
dc.subjectFunção Executiva
dc.subject.otherNeurofibromatosis type I
dc.subject.otherWorking memory
dc.subject.otherArithmetic
dc.subject.otherGenetic modifiers
dc.subject.otherNeuropsychology
dc.subject.otherExecutive functions
dc.titleCOMT Val158Met Polymorphism Is Associated with Verbal Working Memory in Neurofibromatosis Type 1
dc.typeArtigo de periódico
local.citation.epage7
local.citation.issue334
local.citation.spage1
local.citation.volume10
local.description.resumoNeurofibromatosis type I (NF1) is a neurogenetic disease marked by multiple cognitive and learning problems. Genetic variants may account for phenotypic variance in NF1. Here, we investigated the association between the catechol-O-methyltransferase (COMT) Val158Met polymorphism and working memory and arithmetic performance in 50 NF1 individuals. A significant association of the COMT polymorphism was observed only with verbal working memory, as measured by the backward digit-span task with an advantageous performance for Met/Met carriers. To study how genetic modifiers influence NF1 cognitive performance might be of importance to decrease the unpredictability of the cognitive profile among NF1 patients.
local.identifier.orcid0000-0002-9649-867X
local.publisher.countryBrasil
local.publisher.departmentFAF - DEPARTAMENTO DE PSICOLOGIA
local.publisher.departmentMED - DEPARTAMENTO DE PEDIATRIA
local.publisher.departmentMED - DEPARTAMENTO DE SAÚDE MENTAL
local.publisher.initialsUFMG
local.url.externahttps://www.frontiersin.org/articles/10.3389/fnhum.2016.00334/full

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