Relationship between apical periodontitis and atherosclerosis: lipid profile and histological study

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dc.creatorLeticia Citelli Conti
dc.creatorJuan José Segura Egea.
dc.creatorCarolina de Barros Morais Cardoso
dc.creatorFrancine Benetti
dc.creatorMariane Maffei Azuma
dc.creatorPedro Henrique Chaves de Oliveira
dc.creatorSuely Regina Mogami Bomfim
dc.creatorLuciano Tavares Ângelo Cintra
dc.date.accessioned2022-11-28T19:56:53Z
dc.date.accessioned2025-09-09T00:00:53Z
dc.date.available2022-11-28T19:56:53Z
dc.date.issued2020-06-23
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPESP - Fundação de Amparo à Pesquisa do Estado de São Paulo
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1111/iej.13350
dc.identifier.issn01432885
dc.identifier.urihttps://hdl.handle.net/1843/47512
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofInternational Endodontic Journal
dc.rightsAcesso Restrito
dc.subjectPeriapical periodontitis
dc.subjectAtherosclerosis
dc.subjectEndodontics
dc.subjectLipids
dc.subjectInflammation
dc.subjectEndodontics
dc.subject.otherApical periodontitis
dc.subject.otherAtherosclerosis
dc.subject.otherEndodontic medicine
dc.subject.otherSystemic disorders
dc.titleRelationship between apical periodontitis and atherosclerosis: lipid profile and histological study
dc.typeArtigo de periódico
local.citation.epage1397
local.citation.issue10
local.citation.spage1387
local.citation.volume53
local.description.resumoAim: To investigate the relationship between apical periodontitis and atherosclerosis in rats by lipid profile and carotid artery intima tunic measurement, and histological and histometric evaluation of periapical lesions. Methodology: Forty male Wistar rats were allocated into four groups: control (C), with apical periodontitis (AP), with atherosclerosis (AT) and with AP and AT (AP + AT). Atherosclerosis was induced using a high-lipid diet associated with a surgical ligature in the carotid artery and a super dosage of vitamin D3 . AP was induced via pulp exposure to the oral environment. At 45 and 75 days, serum levels of total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) were measured. The maxillary and mandibular jaws and carotid artery were collected and processed for histological analysis. The Kruskal-Wallis or Mann-Whitney test was performed for nonparametric data, and the Tukey's or Student's t-test was performed for parametric data (P < 0.05). Results: In nonatherosclerotic animals, the induction of apical periodontitis increased TG levels significantly, from 63.1 ± 11.4 mg dL-1 in group C to 88.2 ± 7.9 mg dL-1 in the AP group (P < 0.05). The induction of AP was associated with a trend for higher TC and LDL-C levels in atherosclerotic animals (P > 0.05); however, it only significantly increased TG levels, from 93.2 ± 18.0 mg dL-1 in AT group to 121.9 ± 14.5 mg dL-1 in the AP + AT group (P < 0.05). Animals in the AP + AT group had a 36.5% increase in the thickness of the carotid intima tunic when compared with the AT group (P < 0.05). The intensity of the inflammatory infiltrate was significantly larger in the AP + AT group when compared with AP group (P < 0.05). The AP + AT group exhibited significantly greater alveolar bone loss, with a periapical lesion size of 206.4 ± 56.3 × 104 μm2 , compared with 151.4 ± 49.1 × 104 μm2 in the AP group (P < 0.05). Conclusion: Apical periodontitis influenced triglyceride levels, increasing them even in the absence of atherosclerosis, and influenced the increase in the thickness of the carotid artery intima tunic in the presence of atherosclerosis. Atherosclerosis intensified the inflammatory reaction and increased bone resorption in periapical lesions
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORA
local.publisher.initialsUFMG
local.url.externahttps://onlinelibrary.wiley.com/doi/10.1111/iej.13350

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