Nanofibers containing tetracycline/β-cyclodextrin: physico-chemical characterization and antimicrobial evaluation

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dc.creatorAna Paula de Figueiredo Monteiro
dc.creatorCíntia M. S. L. Rocha
dc.creatorMichele Fabiane de Oliveira
dc.creatorSávio Morato Lacerda Gontijo
dc.creatorRicardo Ramírez-Agudelo
dc.creatorRubén Dario Sinisterra Millán
dc.creatorMaría Esperanza Cortés Segura
dc.date.accessioned2023-12-04T13:47:31Z
dc.date.accessioned2025-09-08T23:50:21Z
dc.date.available2023-12-04T13:47:31Z
dc.date.issued2017-01
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.description.sponsorshipINCT – Instituto nacional de ciência e tecnologia (Antigo Instituto do Milênio)
dc.identifier.doihttp://dx.doi.org/10.1016/j.carbpol.2016.09.059
dc.identifier.issn1879-1344
dc.identifier.urihttps://hdl.handle.net/1843/61671
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofCarbohydrate Polymers
dc.rightsAcesso Restrito
dc.subjectTetraciclina
dc.subjectCiclodextrinas
dc.subjectMateriais nanoestruturados
dc.subjectAgentes antiinfecciosos
dc.subjectFísico-química
dc.subjectSistemas de distribuição de medicamentos
dc.subjectSistemas deliberados de drogas poliméricas
dc.subjectDoença periodontal
dc.subjectAnálise térmica
dc.subjectRaios X - Difração
dc.subjectFourier, Espectroscopia de infravermelho por transformada de
dc.subjectMicroscopia eletrônica de varredura
dc.subjectQuímica farmacêutica
dc.subject.otherTetracycline
dc.subject.otherCyclodextrin
dc.subject.otherInclusion compound
dc.subject.otherNanofibers
dc.subject.otherAntimicrobial activity
dc.subject.otherElectrospuna
dc.titleNanofibers containing tetracycline/β-cyclodextrin: physico-chemical characterization and antimicrobial evaluation
dc.typeArtigo de periódico
local.citation.epage426
local.citation.spage417
local.citation.volume156
local.description.resumoThis study aimed to compare two nanofiber drug delivery systems that were prepared with an electrospun process and have the potential to serve as adjuvants for the treatment of periodontal disease. The first system was composed of polycaprolactone loaded with tetracycline (TCN) and the second was composed of polycaprolactone loaded with tetracycline/β-cyclodextrin (TCN:BCD). An antimicrobial diffusion test was performed for each of these sets of nanofibers with the microorganisms, Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis, both of which contribute to periodontal disease. In vitro release profiles were also obtained, and the nanofibers were characterized by thermal analysis, x-ray powder diffraction, infrared absorption spectroscopy, and scanning electron microscopy. Profiles of the TCN and TCN:BCD nanofibers showed that drug release occurred for up to 14 days. However, the TCN:BCD nanofibers appeared to better protect and enhance the biological absorption of TCN due to theformation of a TCN:BCD inclusion complex.
local.identifier.orcidhttps://orcid.org/0000-0002-4202-1964
local.identifier.orcidhttps://orcid.org/0000-0002-7803-4345
local.identifier.orcidhttps://orcid.org/0009-0001-5010-7450
local.identifier.orcidhttps://orcid.org/0000-0001-7656-1849
local.identifier.orcidhttps://orcid.org/0000-0002-0560-8491
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORA
local.publisher.departmentICX - DEPARTAMENTO DE QUÍMICA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S0144861716311134

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